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Laboratory for Translational Neurodegeneration Research

Mission Statement

Our research focuses on basic molecular mechanisms, biomarker discovery and new treatment options for neurodegenerative diseases with special emphasis on α-synucleinopathies including Parkinson’s disease (PD) and Multiple System Atrophy (MSA). We investigate the role of oligomeric α-synuclein to trigger disease-specific phenotypes, the effects of exogenous stress factors and epigenetic modulation in models of α-synucleinopathy, the involvement of glial cells in PD and MSA, and the neuroinflammatory mechanisms associated with α-synuclein pathology. Through preclinical screening and target validation for disease modification, we aim to provide rationale for clinical trials in PD and MSA.

Team

Univ.-Prof. Nadia Stefanova MD, PhD, DSc
Head of Laboratory
nadia.stefanova@i-med.ac.at
Antonio Heras-Garvin PhD
PostDoc
antonio.heras@i-med.ac.at
Alain Ndayisaba MD
PhD Student
alain.ndayisaba@student.i-med.ac.at
Martina Wick MSc
Research Assistant
martina.wick@i-med.ac.at
Eleonore Klippel
Medical Student
eleonore.klippel@student.i-med.ac.at

Former members

Isabella Rathgeb BSc; Miguel Lemos PhD; Patrick Bachmann cand. MD; Katrin Juliana Vouk BSc; Katja Malfertheiner BSc; Lisa Fellner PhD; Claudio Schmidt MSc; Violetta Refolo PhD; Tamina Weiss BSc; Marcos Herrera-Vaquero PhD; Lorenz Härtner PhD; Serena Venezia PhD; Martin Kallab MD; Edith Sturm PhD; Karin Spiss; Christine Kaindlstorfer MD PhD; Florian Krismer MD PhD; Daniela Kuzdas-Wood PhD; Dominik Brück MSc; Michael Lohmüller BSc; Christine Mantinger MD; Patrick Sommer MD; Melanie Premstaller MD; Philipp Hockl MD; Monika Hainzer; Yuntao Li MD; Sonya Neto PhD; Sylvia Stemberger PhD; Philipp Fuchs MD; Julia Kuen MD; Ankit Gupta; Undine Hauser MD; Lucas Mangard MD; Violeta Staeva MD; Harald Granbichler; Laura Mantoan MD; Monika Mitschnigg MD; Theron Sather MD; Sonja Scholz MD; Zoe Puschban MD; Christoph Scherfler MD

Publications