Publications in journals, FWF Project 11301 Regulation of GTP cyclohydrolase I
Ernst R. Werner. Division of Biological Chemistry, Biocenter, Medical University of Innsbruck
Activation of neuronal nitric oxide synthase by the 5-methyl analog of tetrahydrobiopterin. Functional evidence against reductive oxygen activation by the pterin cofactor. Riethmüller, C., Gorren, A. C. F., Pitters, E., Hemmens, B., Habisch, H. J., Heales, S. J. R., Schmidt, K., Werner, E. R., Mayer, B. (1999) J.Biol.Chem. 274, 16047-16051
Preferential inhibition of inducible nitric oxide synthase by the 4-amino analogue of tetrahydrobiopterin in cultured cells. Schmidt, K., Werner-Felmayer, G., Mayer, B., Werner, E. R. (1999) Eur.J.Biochem. 259, 25-31
Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. Cosentino, F., Patton, S., d'Uscio, L. V., Werner, E. R., Werner-Felmayer, G., Moreau, P., Malinski, T., Luscher, T. F. (1998) J.Clin.Invest. 101, 1530-1537
Coordinated induction of inducible nitric oxide synthase and GTP- cyclohydrolase I is dependent on inflammatory cytokines and interferon- gamma in HaCaT keratinocytes: implications for the model of cutaneous wound repair.Frank, S., Kolb, N., Werner, E. R., Pfeilschifter, J. (1998) J.Invest.Dermatol. 111, 1065-1071
Haem insertion, dimerization and reactivation of haem-free rat neuronal nitric oxide synthase. Hemmens, B., Gorren, A. C. F., Schmidt, K., Werner, E. R., Mayer, B. (1998) Biochem.J. 332, 337-342
Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells. Lapize, C., Pluss, C., Werner, E. R., Huwiler, A., Pfeilschifter, J. (1998) Biochem.Biophys.Res.Commun. 251, 802-805
Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites. Steinmetz, M. O., Pluss, C., Christen, U., Wolpensinger, B., Lustig, A., Werner, E. R., Wachter, H., Engel, A., Aebi, U., Pfeilschifter, J., Kammerer, R. A. (1998) J.Mol.Biol. 279, 189-199
Minireview: Tetrahydrobiopterin, cytokines and nitric oxide synthesis. Werner, E. R., Werner-Felmayer, G., Mayer, B. (1998) Proc.Soc.Exp.Biol.Med. 219, 171-182
Tetrahydrobiopterin in the treatment of infantile hypertrophic pyloric stenosis. Braegger, C. P., Schwobel, M., Kanel, J., Werner, E. R., Thony, B., Blau, N. (1997) Biochem.Mol.Med. 62, 101-105
Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction. Ghosh, D. K., Wu, C., Pitters, E., Moloney, M., Werner, E. R., Mayer, B., Stuehr, D. J. (1997) Biochemistry. 36, 10609-10619
Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization. List, B. M., Kloesch, B., Voelker, C., Gorren, A. C. F., Sessa, W. C., Werner, E. R., Kukovetz, W. R., Schmidt, K., Mayer, B. (1997) Biochem.J. 323, 159-165
Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase expressed in Escherichia coli. Heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino tetrahydrobiopterin. Mayer, B., Wu, C., Gorren, A. C. F., Pfeiffer, S., Schmidt, K., Clark, P., Stuehr, D. J., Werner, E. R. (1997) Biochemistry 36, 8422-8427
Interference of Carboxy-PTIO with nitric oxide- and peroxynitrite-mediated reactions. Pfeiffer, S., Leopold, E., Hemmens, B., Schmidt, K., Werner, E. R., Mayer, B. (1997) . Free Rad.Biol.Med. 22, 787-794
Metabolic fate of peroxynitrite in aqueous solution. Reaction with nitric oxide and pH-dependent decomposition to nitrite and oxygen in a 2:1 stoichiometry. Pfeiffer, S., Gorren, A. C. F., Schmidt, K., Werner, E. R., Hansert, B., Bohle, D. S., Mayer, B. (1997) J.Biol.Chem. 272, 3465-3470
Allosteric modulation of rat brain nitric oxide synthase by the pterin-site enzyme inhibitor 4-amino tetrahydrobiopterin. Pfeiffer, S., Gorren, A. C. F., Pitters, E., Schmidt, K., Werner, E. R., Mayer, B. (1997) Biochem.J. 328, 349-352
Differential effect of dexamethasone on interleukin 1beta- and cyclic AMP-triggered expression of GTP cyclohydrolase I in rat renal mesangial cells. Plüss, C., Werner, E. R., Wachter, H., Pfeilschifter, J. (1997) Br.J.Pharmacol. 122, 534-538
Tetrahydrobiopterin-free neuronal nitric oxide synthase: Evidence for two identical highly anticooperative pteridine binding sites. Gorren, A. C. F., List, B. M., Schrammel, A., Pitters, E., Hemmens, B., Werner, E. R., Schmidt, K., Mayer, B. (1996) Biochemistry 35, 16735-16745
Interleukin-1 beta and cAMP trigger the expression of GTP cyclohydrolase I in rat renal mesangial cells. Plüss, C., Werner, E. R., Blau, N., Wachter, H., Pfeilschifter, J. (1996) Biochem.J. 318, 665-671
High performance liquid chromatographic methods for the quantification of tetrahydrobiopterin biosynthetic enzymes. Werner, E. R., Werner-Felmayer, G., Wachter, H. (1996). J.Chromatogr. 684B, 51-58
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