Project Publications, FWF_P22406 Alkylglycerol Monooxygenase: Cloning and Biochemistry,
Ernst R. Werner, Division of Biological Chemistry, Biocenter, Medical University of Innsbruck
Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. Watschinger K, Keller MA, Golderer G, Hermann M, Maglione M, Sarg B, Lindner HH, Hermetter A, Werner-Felmayer G, Konrat R, Hulo N, Werner ER. Proc.Natl.Acad.Sci.U.S.A (2010) 107: 13672-13677
Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol monooxygenase. Watschinger K, Fuchs JE, Yarov-Yarovoy V, Keller MA, Golderer G, Hermetter A, Werner-Felmayer G, Hulo N, Werner ER. Biochem.J. (2012), 443: 279 - 286
Studying fatty aldehyde metabolism in living cells with pyrene-labeled compounds. Keller MA, Watschinger K, Lange K Golderer G, Werner-Felmayer G, Hermetter A, Wanders RJ, Werner ER. J Lipid Res (2012), 53: 1410 - 1416.
Orphan enzymes in ether lipid metabolism. Watschinger K Werner ER. Biochimie (2013), 95: 59-65.
Alkylglycerol monooxygenase. Watschinger K Werner ER. IUBMB Life (2013), 65: 366 -372.
The role of coproporphyrinogen III oxidase and ferrochelatase genes in heme biosynthesis and regulation in Aspergillus niger. Franken AC, Werner ER, Haas H, Lokman BC, van den Hondel CA, Ram AF, de WS, Punt PJ. Appl Microbiol Biotechnol (2013), 97: 9773-9785
A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.Keller MA, Zander U, Fuchs JE, Kreutz C, Watschinger K, Mueller T, Golderer G, Liedl KR, Ralser M, Krautler B, Werner ER, Marquez JA. Nat.Commun. (2014); 5:4439
Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome. Watschinger K, Keller MA, McNeill E, Alam MT, Lai S, Sailer S, Rauch V, Patel J, Hermetter A, Golderer G, Geley S, Werner-Felmayer G, Plumb RS, Astarita G, Ralser M, Channon KM, Werner ER, Proc.Natl.Acad.Sci.U.S.A (2015) 112: 2431-2436
Cuticle Integrity and Biogenic Amine Synthesis in Caenorhabditis elegans Require the Cofactor Tetrahydrobiopterin (BH4). Loer CM, Calvo AC, Watschinger K, Werner-Felmayer G, O'Rourke D, Stroud D, Tong A, Gotenstein JR, Chisholm AD, Hodgkin J, Werner ER, Martinez A. Genetics (2015) 10.1534/genetics.114.174110
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