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Eco- & Nutritional Biochemistry & Nutrigenomics

Group leader: Ao. Univ. Prof. Mag. Dr. Florian Überall, Retired

We are interested in cellular communication systems. By applying system biological approaches we study the properties and functions of natural products, volatile organic compounds (VOCs) and phytochemicals on human cell systems.

Amongst other project, these are the most recent major accomplishments:

2013-2016 KITCHEN APPLIANCES (FFG-HQ-Project): Development of new kitchen appliances for healthier cooking.

2012-2014 VocOnCell (FFG-bridge project): Cellular and molecular risk assessment of volatile organic compounds from wood-based materials on human cell models using a new type of emission and exposure chamber.

2012-2013 PHYTORAF I&II (Intelligent technologies bmvit): Analysis of bioactive extracts – cascading use of waste from plant harvest and processing.

Mode of action analysis of plant derived allelochemicals on microbes and human cell systems, a proof of principle study.

2008-2011 PHYTEST (FFG-bridge project): Establishment of in-vitro models for a risk-benefit assessment of phytochemicals.

Follow up: Together with a commercial partner in Switzerland we investigate the fundamental regulation of allelochemicals in plants. Additionally, we aim to examine their activities on microbes and human cell models.

Main research focus:

• Deeper insights into inter- and intracellular communication systems
• Signal transduction of natural & volatile organic compounds
• Identification of gene expression signatures
• Genome-wide pathway and network analysis
• Functional characterisation of the interactome
• Profound understanding of the cellular redox-regulated pathways
• Identification on new key players in PKC signaling
• NUTRIGENOMICS
• VOLATILOMICS

 Major achievements

• Activity monitoring of natural products, volatile organic compounds (VOCs) and phytochemicals on cell models in vitro
• Identification and quantification of bioactive organic compounds  from plants, microbes and human cell systems
• Identification of novel endogenous protein kinase C (PKC) epsilon substrates
• Scientific cooperations: Characterization of abiotic stress factors of cyanobacteria - isolation of active principles (Associate Prof. Priv-Doz. Dr. M. Ganzera, Institute for Pharmacy and Pharmacognosy, LFU, FWF-project)

WORKGROUP

Group leader:

Ao. Univ. Prof. Mag. Dr. Überall Florian, PhD

• Predoctoral studies at University of Innsbruck, Austria (Mag.rer.nat. in Microbiology, MSc in Medical Chemistry and Biochemistry)
• 1992 - PhD in Biochemistry, , Medical University of Innsbruck
• Postdoctoral work (1992)
• Team Leader (since 1994)
• Staff Scientist (1994)
• Associate Professor for Medical Biochemistry (1999)
• Secretary-General Austrian Society of Biochemistry and Molecular Biology (since 1999)

• • • CURRICULUM VITAE
      
    • PUBLICATIONS

Teaching lectures and seminars

• Practical courses in biochemistry for medical students
• Scientific working for advanced students
• Special lecture: Biochemical aspects in nutritional science & nutrigenomics
• Interdisciplinary seminars: Molecular Signal transduction

Scientific staff

Scientific staff of the recent past

MMag. Dr. Gruber Peter                                     >> Publications

MSc. Überall Simon 

Mag. Dr. Klein Angela

Mag. Dr. Jenny Marcel

Dipl.-Ing. Mag. Dr. Wrulich Oliver

MSc. PhD Becker Kathrin

Dipl.-Ing. Zeisler Hannes

Mag. Dr. Gostner Johanna                                  >> Publications

Recent pulications

• Gostner, J. M., Raggl, E., Becker, K., Ueberall, F., Schennach, H., Pease, J. E., & Fuchs, D. (2015). Bisphenol A suppresses Th1-type immune response in human peripheral blood mononuclear cells in vitro. Immunology letters.
  
  
• Gostner, J. M., Becker, K., Ueberall, F., & Fuchs, D. (2015). The good and bad of antioxidant foods: An immunological perspective. Food and Chemical Toxicology, 80, 72-79.
  
  
• Gostner, J. M., Schroecksnadel, S., Jenny, M., Klein, A., Ueberall, F., Schennach, H., & Fuchs, D. (2015). Coffee extracts suppress tryptophan breakdown in mitogen-stimulated peripheral blood mononuclear cells. Journal of the American College of Nutrition, (ahead-of-print), 1-12.
  
  
• Gostner, J. M., Ganzera, M., Becker, K., Geisler, S., Schroecksnadel, S., Überall, F., ... & Fuchs, D. (2014). Lavender oil suppresses indoleamine 2, 3-dioxygenase activity in human PBMC. BMC complementary and alternative medicine, 14(1), 503.
  
  
• Geisler, S., Gostner, J. M., Becker, K., Ueberall, F., & Fuchs, D. (2013). Immune activation and inflammation increase the plasma phenylalanine-to-tyrosine ratio. Pteridines, 24(1), 27-31.

• Becker K, Schroecksnadel S, Gostner J, Zaknun C, Schennach H, Uberall F, Fuchs D.: Comparison of in vitro tests for antioxidant and immunomodulatory capacities of compounds. Phytomedicine. 2013 Sep 13. doi:pii: S0944-7113(13)00311-5. 10.1016/j.phymed.2013.08.008.
  
  

• Becker K, Fuchs D, Gostner J, Überall F. Immunomodulatory properties of cacao extracts – potential consequences of medical application. Frontiers in Pharmacology 2013, doi: 10.3389/fphar.2013.00154

• Gostner JM, Gruber P, Becker K, Naschberger M, Uberall F.: [New approaches to elucidate the activities of botanical multi-component mixtures.] Forsch Komplementmed. 2013; 20 Suppl 2:41-4. doi: 10.1159/000351739. 2013 Jun 21. German.

• Klein A, Wrulich OA, Jenny M, Gruber P, Becker K, Fuchs D, Gostner JM, Uberall F.: Pathway-focused bioassays and transcriptome analysis contribute to a better activity monitoring of complex herbal remedies. BMC Genomics. 2013 Feb 27;14:133. doi: 10.1186/1471-2164-14-133. IF: 4,07

• Huemer HP, Geiger M, Posch W, Krumböck N, Fresser F, Wilflingseder D, Uberall F.: Protein kinase C overexpression does not enhance immune-stimulatory surface markers of vaccinia-infected dentritic cells and DC cell lines. Immunol Invest. 2013;42(2):164-77. doi: 10.3109/08820139.2012.750340. 

• Gostner, JM.; Wrulich, OA.; Jenny, M.; Fuchs, D.; Ueberall, F.: An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field. BMC Complement Altern Med. 2012 Mar 14; 12:18. IF: 2

• Crespo, JA.; Stöckl, P.; Ueberall, F.; Jenny, M.; Saria, A.; Zernig, G.: Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory. PLoS One. 2012; 7 (2): e30502, IF: 4,092

• Toton, E.; Lisiak, N.; Rubis, B.; Budzianowski, J.; Gruber, P.; Hofmann, J.; Rybczynska, M.: The tetramethoxyflavone zapotin selectivity activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease. Eur J Pharmacol. 2012; 682(1-3); 21-8. IF: 2,516

• Maglione, M.; Cardini, B.; Oberhuber, R.; Watschinger, K.; Jenny, M.; Gostner, J.; Hermann, M.; Obrist, P.; Margreiter, R.; Pratschke, J.; Brandacher, G.; Werner, ER.: Prevention of lethal murine pancreas ischemia reperfusion injury is specific for tetrahydrobiopterin. Transpl Int. 2012; 25(10), 1084-95. IF: 2,921

• Ciardi, C.; Jenny, M.; Tschoner, A.; Ueberall, F.; Patsch, J.; Pedrini, M.; Ebenbichler, C.; Fuchs, D.: Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro. Br J Nutr. 2012, 107(6), 826-33. IF: 3,013

• Gostner, JM.; Schröcksnadel, S.; Becker, K.; Jenny, M.; Schennach, H.; Überall, F.; Fuchs, D.: Antimalarial drug chloroquine counteracts activation of indoleamine (2,3)-dioxygenase activity in human PBMC. FEBS Open Bio 2012. Volume 2, p 241-245.

• Huemer, HP.; Geiger, M.; Posch, W.; Krumböck,. N.; Fresser, F.; Wilflingseder. D.; Überall, F.: Protein kinase C overexpression does not enhance immune-stimulatory surface markers of vaccinia-infected dendritic cells and DC cell lines. Immunological Investigations, accepted. IF: 1,164

• Eisenstecken, E.; Gostner, JM.; Fuchs, D.; Überall, F.: Molekulare Stoffwechselsensorik bei durch Adipositas induzierter Entzündung. Swiss J Integr Med 2012. 4, 221-231.

• Schroecksnadel, S.; Gostner, JM.; Schennach, H.; Ueberall, F.; Fuchs, D.; Jenny, M.: Peripheral blood mononuclear cells versus myelomonocytic cell line THP-1 to test for immunomodulatory properties of chemicals. J Bionanosci 2012. 6, 1-9.

• Schroecksnadel, S.; Zaknun, C.; Schennach, H.; Jenny, M.; Fuchs, D.: Comparison of in vitro tests for antioxidant capacities and immunomodulatory properties of chemicals. J Bionanosci 2012. 6, 1-7.

Recent contributions to congresses

• Naschberger, M.; Hochleitner, J.; Gostner, JM.; Tonissen, K.; Überall, F.: The Bidirectional Function of Dietary Phytochemicals - Redox balance & the effect of electrophilic attacks. International Summer School on Polyphenols 2015. TU Dresden, Germany.
  
  
• Hochleitner, J.; Naschberger, M.; Gruber, P.; Becker, K.; Fuchs, D.; Ueberall, F.; Gostner, JM.: Suppression of CYP2D6 activity by phytotherapeutics. 6th life science meeting 2014. CCB Innsbruck Universities, Austria.

• Gostner, JM.; Gruber, P.; Zeisler, J.; Ueberall, S.; Martini, S.; Ueberall, F.: Exposure of A549 air-liquid-interphase cultures with 0.1 ppm formaldehyde by using novel exposure incubator system BarbaRA1.0. Annual ÖGMBT Meeting 2013. CCB, Innsbruck (A)

• Ueberall, S.; Zeisler, J.; Gostner, JM.; Gruber, P.;  Kleinhappl, M.; Ueberall, F.: Quality management for the exposure incubator system BarbaRA1.0. Annual ÖGMBT Meeting 2013. CCB, Innsbruck (A)

• Becker, K.; Naschberger, M.; Geisler, S.; Fuchs, D.; Ueberall, F.; Gostner, JM.: Immunomodulatory properties of the Ayurvedic preparation Triphala. Annual ÖGMBT Meeting 2013. CCB, Innsbruck (A)

• Ebner, M.; Gostner, JM.; Trockenbacher, A.; Jenny, M.; Ueberall, F.; Gruber, P.: T-complex polypeptide-1gamma (CCT3) - a novel atypical protein kinase C-interacting protein. Annual ÖGMBT Meeting 2013. CCB, Innsbruck (A)

• Becker, K.; Klein, A.; Wrulich, OA.; Gruber, P.; Fuchs, D.; Jenny, M.; Ueberall, F.; Gostner, JM.: Transcriptome analysis in HepG2 cells revealed multiple activity mechanisms of a Tibetan polyherbal formula. Phytotherapeutika 2012

• Gostner, JM.; Wrulich, OA.; Jenny, M.; Gruber, P.; Becker, K.; Fuchs, D.; Ueberall, F.: An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field. Phytotherapeutika 2012

• Müller, W.; Kollreider, M.; Gostner, JM.; Wrulich OA.; Überall, F.: PADMA Circosan in the Treatment of Periodontal Disease: A Case Report with 60 Patients. Phytotherapeutika 2012

• Gostner, J.; Wrulich, O.; Jenny, M.; Gruber, P.; Becker, K.; Ueberall, F.: Micoarray-based gene expression profiling: possibilities and limitations. 31st International Winter-Workshop Clinical, Chemical and Biochemical Aspects of Pteridines & Exposure to Nanoparticles in Human Populations: Immune System Biomarkers in vitro and in vivo. St Christoph, Arlberg (A)

• Gostner, J.; Schröcksnadel, S.; Jenny, M.; Schennach, H.; Überall, F.; Fuchs, D.: The antimalarial drug chloroquine exhibits immunomodulatory properties in vitro. 31st International Winter-Workshop Clinical, Chemical and Biochemical Aspects of Pteridines & Exposure to Nanoparticles in Human Populations: Immune System Biomarkers in vitro and in vivo. St Christoph, Arlberg (A)

• Becker, K.; Gostner, J.; Klein, A.; Schroecksnadel, S.; Magnus, B.; Jenny, M.; Fuchs, D.; Ueberall, F.: Ayurvedic myrobalane extracts inhibit LPS-induced tryptophan breakdown in THP-1 cells. 31st International Winter-Workshop Clinical, Chemical and Biochemical Aspects of Pteridines & Exposure to Nanoparticles in Human Populations: Immune System Biomarkers in vitro and in vivo. St Christoph, Arlberg (A)

Contact

Center for Chemistry and Biomedicine

Division of Medical Biochemistry

Eco- & Nutritional Biochemistry & Nutrigenomics

Innsbruck Medical University

Innrain 80-82, 4.OG,

6020 Innsbruck, Austria

Telephone: ++43-512-507-70120-22

Collaborations (In alphabetical order)

• Altieri D, Serine-threonine phosphorylation of surviving, Yale, USA
• Biden T, Atypical PKC-iota in insulin signalling, Melborne, Australia
• Fuchs D, Biological chemistry, Medical University Innsbruck, Austria
• Ganzera M, Institute for Pharmacy and Pharmacognosy, Abiotic stress in cyanobacteria (FWF), Innsbruck, Austria
• Hermann M, Confocal microscopy, Medical University Innsbruck, Austria
• Keyse S, Role of ERK specific phosphatases, London, UK
• Kleinhappl M, Gasification processes, BIOENERGY 2020+ GmbH, Graz, Austria
• Mizukami, Tokyo, Japan PKC isotypes and reoxygenation.
• Moscat J, Protein kinase C signalling, Genome Research Institut Cincinnati, USA
• Pestell R, New York, USA Cyclin D1 signal transmission. Role of PKC isotypes.
• Quinn R, Natural compounds, Griffith University, Australia
• Schwabl H, Institute for Nonlinear Studies, Zürich Switzerland
• Schwarzentruber P, Pyroseqencing of microbioms, OMYA, Oftringen, Switzerland
• Steinwender M, Wood competence center, Unterradlberg, Austria
• Tonissen K, Nrf2 & Thioredoxin, Griffith University, Australia
• Troppmaier J, Raf signaling networks, Innsbruck, Austria
• Ullrich A, Martinsried, Germany Signaling of Trk- and EGF receptor mutants.
• Ulrich-Merzenich G, New perspectives for synergy research with the „omics“-technologies in phytomedicine, Bonn, Germany
• Zanella A, Agricultural science, Laimburg, South Tyrol, Italy