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Priv.-Doz. Ingo Bauer PhD, senior scientist

EMail: ingo.bauer[at]i-med.ac.at

Phone: +43/(0)512/9003-70225

Fax: +43/(0)512-9003-73100

Short curriculum

Research fields

• Structure & Function of Chromatin: Filamentous Fungi

Publications

1. Moreno, S., Fickl, M., Bauer, I., Brunner, M., Rázková, A., Rieder, D., Delazer, I., Micura, R., Lusser, A. (2022). 6-thioguanosine monophosphate prodrugs display enhanced performance against thiopurine-resistant leukemia and breast cancer cells. J Med Chem, 65(22):15165–15173. doi: 10.1021/acs.jmedchem.2c01010
   
   
2. Bauer, I., Abt, B., Yap, A., Leuchtle, B., Haas, H. (2022). Online Biomass Monitoring Enables Characterization of the Growth Pattern of Aspergillus fumigatus in Liquid Shake Conditions. J. Fungi 8, 1013. doi: 10.3390/jof8101013
   
   
3. Karahoda, B., Pardeshi, L., Ulas, M., Dong, Z., Shirgaonkar, N., Guo, S., Wang, F., Tan, K., Sarikaya-Bayram, Ö., Bauer, I., Dowling, P., Fleming, A.B., Pfannenstiel, B.T., Luciano-Rosario, D., Berger, H., Graessle, S., Alhussain, M.M., Strauss, J., Keller, N.P., Wong, K.H., Bayram, Ö. (2022). The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis. Nucleic Acids Res 50(17):9797–9813. doi: 10.1093/nar/gkac744
   
   
4. Schoberleitner, I., Mertens, B., Bauer, I., Lusser, A. (2022). Regulation of sensory perception and motor abilities by brain-specific action of chromatin remodeling factor CHD1. Front Mol Neurosci 15:840966. doi: 10.3389/fnmol.2022.840966
   
   
5. Bauer, I. and Graessle, S. (2021). Fungal Lysine Deacetylases in Virulence, Resistance, and Production of Small Bioactive Compounds. Genes 12,1470. doi: 10.3390/genes12101470
   
   
6. Schoberleitner I., Bauer I., Huang A., Andreyeva E.N., Sebald J., Pascher K., Rieder D., Brunner M., Podhraski V., Oemer G., Cázarez-García D., Rieder L., Keller M.A., Winkler R., Fyodorov D.V., Lusser A. (2021). CHD1 controls H3.3 incorporation in adult brain chromatin to maintain metabolic homeostasis and normal lifespan. Cell Rep 37, 109769. doi: 10.1016/j.celrep.2021.109769
   
   
7. Dietl A.M., Binder U., Bauer I., Shadkchan Y., Osherov N., and Haas H. (2020).  Arginine Auxotrophy Affects Siderophore Biosynthesis and Attenuates Virulence of Aspergillus fumigatus. Genes 11, 0423. 2020. doi: 10.3390/genes11040423
   
   
8. Birštonas, L., Dallemulle, A., López-Berges, M.S., Jacobsen, I.D., Offterdinger M., Abt B., Straßburger M., Bauer I., Schmidt O., Sarg B., Lindner H., Haas H., Gsaller F. (2020). Multiplex Genetic Engineering Exploiting Pyrimidine Salvage Pathway-Based Endogenous Counterselectable Markers. mBio 11, e00230–20. doi: 10.1128/mBio.00230-20
   
   
9. Bauer, I., Gross S., Merschak, P., Kremser, L., Karahoda, B., Sarikaya Bayram, Ö., Abt, B., Binder, U., Gsaller, F., Lindner, H., Bayram, Ö., Brosch, G. and Graessle, S. (2020). RcLS2F – A Novel Fungal Class 1 KDAC Co-repressor Complex in Aspergillus nidulans. Front Microbiol 11:43. doi: 10.3389/fmicb.2020.00043
   
   
10. Bauer, I., Misslinger, M., Shadkchan, Y., Dietl, A.M., Petzer, V., Orasch, T., Abt, B.,  Graessle, S., Osherov, N. and Haas, H. (2019). The Lysine Deacetylase RpdA Is Essential for Virulence in Aspergillus fumigatus. Front Microbiol 10:2773. doi: 10.3389/fmicb.2019.02773
    
    
11. Orasch T., Dietl A.M., Shadkchan Y., Binder U., Bauer I., Lass-Flörl C., Osherov N., Haas H. (2019). The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence in Aspergillus fumigatus. Virulence 10, 925-934. doi: 10.1080/21505594.2019.1682760
    
    
12. Bauer, I., Pidroni, A., Bayram, Ö., Brosch, G., Graessle, S. (2019). Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay. J Vis Exp 147: e59527. doi: 10.3791/59527
    
    
13. Bauer, I., Lechner, L., Pidroni, A., Petrone, A., Merschak, P., Lindner, H., Kremser, L., Graessle, S., Golderer, G., Allipour, S. and Brosch, G. (2019). Type I and II PRMTs regulate catabolic as well as detoxifying processes in Aspergillus nidulans. Fungal Genet and Biol 129, 86-100. doi: 10.1016/j.fgb.2019.05.006
    
    
14. Binder U., Navarro-Mendoza M.I., Naschberger V., Bauer I., Nicolas F.E., Pallua J.D., Lass-Flörl C., Garre V. (2018). Generation of A Mucor circinelloides Reporter Strain-A Promising New Tool to Study Antifungal Drug Efficacy and Mucormycosis. Genes (Basel). pii: E613. doi: 10.3390/genes9120613
    
    
15. Pidroni A., Faber B., Brosch G., Bauer I. and Graessle S. (2018). A Class 1 Histone Deacetylase as Major Regulator of Secondary Metabolite Production in Aspergillus nidulans. Front Microbiol 9:2212. doi: 10.3389/fmicb.2018.02212
    
    
16. Bauer I., Varadarajan D., Pidroni A., Gross S., Vergeiner S., Faber B., Herrmann M., Tribus M., Brosch G., Graessle S. (2016). A class 1 histone deacetylase with potential as an antifungal target. mBio 7(6):e00831-16. doi: 10.1128%2FmBio.00831-16 
    
    
17. Bauer, I., Graessle, S., Loidl, P., Hohenstein, K., Brosch, G. (2010). Novel insights into the functional role of three protein arginine methyltransferases in Aspergillus nidulans. Fungal Genetics and Biology 47(6):551-61. doi: 10.1016/j.fgb.2010.03.006  
    
    
18. Castellano, S., Milite, C., Ragno, R., Simeoni, S., Mai, A., Limongelli, V., Novellino, E., Bauer, I., Brosch, G., Spannhoff, A., Cheng, D., Bedford, M.T., Sbardella, G. (2010). Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). Chem Med Chem 5(3), 398-414. doi: 10.1002/cmdc.200900459 
    
    
19.  Bauer, I., Tribus, M., Galehr, J., Rieser, G., Brosch, G., Loidl, P., Trojer, P., Haas, H. and Graessle, S. (2010). A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus. Molecular Biology of the Cell Vol. 21, 345-353. doi: 10.1091/mbc.E09-08-0750
    
    
20. Heinke R., Spannhoff A., Meier R., Trojer P., Bauer I., Jung M., and Sippl W. (2009). Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors. Chem Med Chem 4(1):69-77. doi: 10.1002/cmdc.200800301
    
    
21. Spannhoff A, Machmur R, Heinke R, Trojer P, Bauer I, Brosch G, Schule R, Hanefeld W, Sippl W, Jung M. (2007). A novel arginine methyltransferase inhibitor with cellular activity. Bioorg Med Chem Lett 17, 4150-4153.  doi: 10.1016/j.bmcl.2007.05.088
    
    
22. Ragno, R., Simeoni, S., Castellano, S., Vicidomini, C., Mai, A., Caroli, A., Tramontano, A., Bonaccini, C., Trojer, P., Bauer, I., Brosch, G. and Sbardella, G. (2007). Small Molecule Inhibitors of Histone Arginine Methyltransferases: Homology Modeling, Molecular Docking, Binding Mode Analysis and Biological Evaluations. J Med Chem 50, 1241-1253. doi:  10.1021/jm061213n
    
    
23. Spannhoff, A., Heinke, R., Bauer, I., Trojer, P., Metzger, E., Gust, R., Schuele, R., Brosch, G., Sippl, W. and Jung, M. (2007). Target-based approach to inhibitors of histone arginine methyltransferases. J Med Chem 50, 2319-2325.  doi:  10.1021/jm061250e
    
    
24. Trojer, P., Dangl, M., Bauer, I., Graessle, S., Loidl, P. and Brosch, G. (2004). Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity. Biochemistry 43, 10834-10843. doi: 10.1021/bi049626i