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Lukas Trixl MSc., PhD student

lukas trixlEMail:lukas.trixl[at]i-med.ac.at

Phone: +43/(0)512/9003-70209

Fax: +43/(0)512-9003-73100

 

Short curriculum

2010-2013 Bachelor studies in Biology at the Leopold-Franzens-University, Innsbruck
2013-2016 Master studies in Molecular Cell and Developmental Biology at the Leopold-Franzens-University, Innsbruck
since 2016 PhD program: Regulation of Gene Expression during Growth, Development and Differentiation. Title of PhD thesis:
"Study the biological roles of RNA cytosine methylation"(supervisor: ao.Univ.-Prof.Dr. Alexandra Lusser) at the Institute of Molecular Biology, Biocenter, Innsbruck Medical University

 

Research fields

RNA modifications

  • Cytosine methylation of RNAs
  • RNA methylation as a regulatory unit of cellular processes
  • Enzymes for RNA methylation and their interplay with other proteins

 

Epigenetics

  • Influence of RNA modifications on the function of RNAs in chromatin regulation
  • RNA modifications in cancer cells

 

Publications

  1. Gasser, C., Delazer, I., Neuner, E., Pascher, K., Brillet, K., Klotz, S., Trixl, L., Himmelstoß, M, Ennifar, E., Rieder*, D., Lusser*, A., Micura*, R (2020). Thioguanosine conversion enables mRNA life-time evaluation by RNA sequencing via double metabolic labeling. Angew Chem Int Ed Engl., 1–8. http://doi.org/10.1002/anie.201916272  *co-corresponding authors
  2. Trixl, L., and Lusser, A. (2019). Getting a hold on cytosine methylation in mRNA. Nat. Struct. Mol. Biol. 26(5), 339–340. http://doi.org/10.1038/s41594-019-0217-y (News & Views)

  3. Trixl, L., & Lusser, A. (2019). Publisher Correction: RNA modification: Getting a hold on cytosine methylation in mRNA. Nature Structural & Molecular Biology. http://doi.org/10.1038/s41594-019-0247-5

  4. Trixl L., Rieder D., Amort T., Lusser A. (2019) Bisulfite Sequencing of RNA for Transcriptome-Wide Detection of 5-Methylcytosine. In: Wajapeyee N., Gupta R. (eds) Epitranscriptomics. Methods in Molecular Biology, vol 1870. Humana Press, New York, NY

  5. Trixl L., Lusser A. (2018). The dynamic RNA modification 5‐methylcytosine and its emerging role as an epitranscriptomic mark. WIREs RNA 2018. doi: 10.1002/wrna.1510

  6. Amort, T., Rieder, D., Wille, A., Khokhlova-Cubberley, D., Riml, C., Trixl, L., Jia, X.-Y., Micura, R., and Lusser, A. (2017). Distinct 5-methylcytosine profiles in poly(A) RNA from mouse embryonic stem cells and brain. Genome Biol 18, 1-16. http://dx.doi.org/10.1186/s13059-016-1139-1

  7. Trixl, L., Amort, T., Wille, A., Zinni, M., Ebner, S., Hechenberger, C., Eichin, F., Gabriel, H., Schoberleitner, I., Huang, A., Piatti, P., Nat, R., Troppmair, J., Lusser, A. (2017). RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity. Cell. Mol. Life Sci. https://doi.org/10.1007/s00018-017-2700-0

  8. M. Boltengagen, A. Huang, A. Boltengagen, L. Trixl, H. Lindner, L. Kremser, M. Offterdinger and A. Lusser (2015) “A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster”; Nucleic Acids Research, pp. 1-15

Institut für Molekularbiologie