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Publications:

Book chapters:

Ausserlechner, M. J., J. Hagenbuchner, S. Fuchs, K. Geiger, and P. Obexer. 2011. FOXO transcription factors as potential therapeutic targets in neuroblastoma, pp. 325-348, In H. Shimada [ed.], Neuroblastoma - Present and Future. InTech, Rijeka, Croatia. (open access)

Obexer, P., J. Hagenbuchner, M. Holzner, and M. J. Ausserlechner. 2011. p16INK4A - connecting cell cycle control to cell death regulation in human leukemia, pp. 115-130 In O. Babusikova, S. Dovat, and K. S. Payne [eds.], T-cell Leukemia. InTech, Rijeka, Croatia. (open access)

Original Papers:

Hagenbuchner J., Scholl-Buergi, S., Karall, D., Ausserlechner, M.J. (2018) Very long-/ and long Chain-3-Hydroxy Acyl CoA Dehydrogenase Deficiency correlates with deregulation of the mitochondrial fusion/fission machinery. Scientific Reports, in press

Rupp M., Hagenbuchner J., Rass B., Fiegl H., Kiechl-Kohlendorfer U., Obexer P., Ausserlechner M.J. (2017) FOXO3-mediated chemo-protection in high-stage neuroblastoma depends on wild-type TP53 and SESN3. Oncogene. 36(44): 6190-6203. doi: 10.1038/onc.2017.288.

Salcher S., Hermann M., Kiechl-Kohlendorfer U., Ausserlechner M.J., Obexer P. (2017) C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy. Mol Cancer. 16(1):95. doi: 10.1186/s12943-017-0661-4.

Hagenbuchner, J., Lungkofler, L., Kiechl-Kohlendorfer, U., Viola, G., Ferlin, M.G., Ausserlechner, M.J., Obexer, P. (2017) The tubulin-inhibitor MG-2477 induces autophagy-regulated cell death and activation of FOXO3 in neuroblastoma. Oncotarget, 8(19):32009-32026.

Hagenbuchner, J.^#, Rupp, M.^#, Salvador, C., Meister, B.,  Kiechl-Kohlendorfer, U., Thomas Müller, T., Geiger, K.,Sergi, C., Obexer, P., Ausserlechner, M.J. (2016) Nuclear FOXO3 predicts adverse clinical outcome and promotes tumorangiogenesis in neuroblastoma in vivo. Oncotarget, 7(47):77591-77606. doi: 10.18632/oncotarget.12728.

Hagenbuchner J., Kiechl-Kohlendorfer U., Obexer P., Ausserlechner M.J. (2016) BIRC5/Survivin as target for glycolysis inhibition in high-stage neuroblastoma. Oncogene, 35(16):2052-61. doi: 10.1038/onc.2015.264.

Schäfer S, Salcher S, Seiter M, Ranninger C, Möst M, Obexer P, Huber CG, Ausserlechner M.J., Schwaiger S, Stuppner H (2016). Characterization of the XIAP-Inhibiting Proanthocyanidin Fraction of the Aerial Parts of Ephedra sinica. Planta Med. 82(11-12):973-85. doi: 10.1055/s-0042-107253.

Hagenbuchner J., and Ausserlechner M.J. (2016). Transcription factors as drug targets for small chemical compounds. Biochemical Pharmacology, 107:1-13. doi: 10.1016/j.bcp.2015.12.006 (IF 5.0)

Ausserlechner M.J., Hagenbuchner J. Mitochondrial survivin – an Achilles’ heel in cancer chemoresistance (2015). Molecular and Cellular Oncology, (invited Author’s view), 29;3(2):e1076589. doi: 10.1080/23723556.2015.1076589.

Obexer, P., Ausserlechner, M.J. (2014) X-linked inhibitor of apoptosis (XIAP) – a critical death-resistance regulator and therapeutic target for personalized cancer therapy. Frontiers in Oncology, 4:197

Salcher S, Hagenbuchner J, Geiger K, Seiter M.A., Rainer J, Kofler R, Hermann M, Kiechl-Kohlendorfer U, Ausserlechner M.J.*, Obexer P. (2014) C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma, Mol Cancer. 13(1):224. *correspond author

Seiter, M.A., Salcher, S., Rupp, M., Hagenbuchner, J., Kiechl-Kohlendorfer, U., Mortier, J., Wolber, G., Rollinger, J.M, Obexer, P., Ausserlechner, M.J. (2014) Discovery of Sanggenon G as a natural cell-permeable small-molecular weight inhibitor of X-linked inhibitor of apoptosis protein (XIAP), FEBS Open Bio, 4: 659

Hagenbuchner,J. and Ausserlechner, M.J. (2013) Mitochondria and FOXO3: breath or die. Front Physiol., 4:147.

Hagenbuchner,J., Kiechl-Kohlendorfer,U., Obexer,P. and Ausserlechner,M.J. (2013) A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration. Oncotarget. 4(8):1241-52.

Ausserlechner,M.J., Salvador,C., Deutschmann,A., Bodner,M., Viola,G., Bortolozzi,R., Basso,G., Hagenbuchner,J. and Obexer,P. (2013) Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa. Oncotarget, 4(7): 995- 1007.  

Hagenbuchner J, Kuznetsov AV, Obexer P, and Ausserlechner MJ, BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery (2013), Oncogene, 32(40):4748-57.

Geiger, K.*, Hagenbuchner, J.*, Rupp, M., Fiegl, H., Sergi, C., Meister, B., Kiechl-Kohlendorfer, U., Müller, T., Ausserlechner, M.J.and Obexer, P. (2012). FOXO3/FKHRL1 is activated by 5-Aza-2-deoxycytidine (5-azadC) and induces silenced Caspase-8 in neuroblastoma. in press  *contributed equally to this work

Hagenbuchner, J., Kuznetsov A. V., Hermann M., Hausott B., Obexer P. and Ausserlechner M. J. (2012). FOXO3-induced reactive oxygen species are regulated by BCL2L11/Bim and SESN3. J. Cell Sci.epub.

Hagenbuchner, J., Ausserlechner, MJ., Porto, V., David, R., Meister, B., Bodner, M., Villunger, A., Geiger, K., Obexer, P. (2010) The Antiapoptotic Protein BCL2L1/BCL-XL is Neutralized by Proapoptotic PMAIP1/Noxa in Neuroblastoma Thereby Determining Bortezomib-Sensitivity Independent of Prosurvival MCL1 Expression. J Biol Chem. 2010 Mar 5;285(10):6904-12. 

Berger, R., Fiegl, H., Goebel, G., Obexer, P., Ausserlechner, MJ., Doppler, W., Hauser-Kronberger, C., Reitsamer, R., Egle, D., Reimer, D., Müller-Holzner, E., Jones, A., Widschwendter, M. (2010) Toll-like Receptor-9 expression in breast and ovarian cancer is associated with poorly differentiated tumors.  Cancer Science, 2010, Apr;101(4):1059-66 

Tominaga, K., Tominaga, E., Ausserlechner, MJ., Pereira-Smith, OM. (2010) The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway. Exp.Cell Res. 360(1): 92-102

Obexer, P., Hagenbuchner, J., Rupp, M., Salvador, C., Holzner, M., Deutsch, M., Porto, V., Kofler, R., Unterkircher, T., Ausserlechner, MJ. (2009) p16^INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2. Journal of Biological Chemistry 284(45): 30933-40

Obexer, P., Hagenbuchner, J., Unterkircher, T., Sachsenmaier, N., Seifarth, C., Böck, G., Porto, V., Geiger,  K., Ausserlechner, MJ. (2009) Repression of BIRC5/Survivin by FOXO3/FKHRL1 sensitizes human neuroblastoma cells to DNA-damage-induced apoptosis.  Molecular Biology of the Cell,20(7), 2041-48

Prelog, M., Schwarzenbrunner, N., Sailer-Höck, M., Kern, H,. Klein-Franke, A., Ausserlechner, MJ., Koppelstaetter, C., Brunner, A., Duftner, C., Dejaco, C., Strasak, AM., Müller, T., Zimmerhackl, LB., Brunner, J. (2008) Premature aging of the immune system in children with juvenile idiopathic arthritis. Arthritis and Rheumatism, 58(7):2153-62 

Nguyen, VA., Fürhapter, C., Obexer, P., Stössel, H., Romani, N., Sepp, N. Endothelial cells from cord blood CD133(+)CD34(+) progenitors share phenotypic, functional and gene expression profile similarities with lymphatics. (2008). J Cell Mol Med. 13(3): 522-34 

Spoden GA, Mazurek S, Morandell D, Bacher N, Ausserlechner MJ, Jansen-Dürr P, Eigenbrodt E, Zwerschke W. (2008) Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation., Int J Cancer. 123(2):312-21

Obexer, P., Geiger, K., Ambros, P., Meister, B., Ausserlechner, M.J. (2007) FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells. Cell Death and Differentiation, 14(3), 534-47 

Ausserlechner, M.J., Obexer, P., Geiger, K., Deutschmann, A., Kofler, R. (2006) A retroviral expression system based on tetracycline-regulated tricistronic transactivator/repressor vectors for functional analyses of anti-proliferative and toxic genes. Molecular Cancer Therapeutics, 5(8), 1927-34

Bacher, N., Tiefenthaler, M., Sturm, S., Stuppner, H., Ausserlechner, M. J., Kofler, R., Konwalinka, G. (2006) Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2 expressing acute lymphoblastic leukaemia cells. Brit. J. Haemat. 132(5), 615-622

Ausserlechner, M. J., Obexer, P., Geley, S., Kofler, R. (2005) G1-arrest by p16^INK4A Uncouples Growth from Cell Cycle Progression in Leukemic Cells with Deregulated Cyclin E and c-Myc. Leukemia, 19(6), 1051-1057 

Agu, C.A., Klein, R., Schwab, S., Konig-Schwab, M., Kodajova, P., Ausserlechner, M. J., Binishofer, B., Blasi, U., Salmons, B., Günzburg, W. H., Hohenadl, C. (2006) The cytotoxic activity of the bacteriophage lambda-holin protein reduces tumour growth rates in mammary cancer cell xenograft models. J. Gene Med. 8(2), 229-241

*Hainz, U., *Obexer, P., Winkler, Ch., Sedlmayr, P., Takikawa, O., Greinix, H., Lawitschka, A., Fuchs, D., Pötschger, U., Ladisch, St., Heitger, A. (2005) Monocyte mediated T cell suppression and augmented monocyte tryptophan catabolism after human hematopoietic stem cell transplantation. Blood. 105(10):4127-34, * contributed equally to this work

Ausserlechner, M. J., Obexer, P., Böck, G., Geley, S., and Kofler, R. (2004). Cyclin D3 and c-Myc Control Glucocorticoid-induced Cell Cycle Arrest but not Apoptosis in Lymphoblastic Leukemia Cells. Cell Death and Differentiation, 11(2), 165-174.

Riml, S., Schmidt, S., Ausserlechner, M.J., Geley, S., Kofler, R. (2004). Glucocorticoid receptor heterozygosity combined with lack of receptor auto-induction causes glucocorticoid resistance in Jurkat acute lymphoblastic leukemia cells. Cell Death and Differentiation, 11(S1), 65-72 

Villunger, A., Michalak, E., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M.J., Adams, J.M., Strasser, A. (2003). BH3-only Proteins Puma/Bbc3 and Noxa Are Limiting for Cytotoxic Drug-Induced Apoptosis. Science, 302, 1036-1038.

Renner, K., Ausserlechner, M.J., Kofler, R. (2003). A Conceptual View on Gluco­corticoid-Induced Apoptosis, Cell Cycle Arrest and Glucocorticoid Resistance in Lymphoblastic Leukemia.  Current Molecular Medicine, 3, 707-717.

Kofler, R., Schmidt, S., Kofler, A., Ausserlechner, M.J., (2003) Resistance to Glucocorticoid-induced Apoptosis in Lymphoblastic Leukemia. J. Endocrinology, 178, 19-27.

Heitger, A., Winklehner, P., Obexer, P., Eder, J., Zelle-Rieser, C., Kropshofer, G., Thurnher, M. and Holter, W. (2002) Defective T-helper cell function after T-cell depleting therapy affecting naive and memory populations. Blood;99(11):4053-4062

Obexer, P., Certa, U., Kofler, R., and Helmberg, A. (2001) Expression profiling of glucocorticoid-treated T-all cell lines: rapid repression of multiple genes involved in RNA-, protein- and nucleotide synthesis. Oncogene 20(32): 4324-36 

Ausserlechner, M. J., Obexer, P., Wiegers, G. J., Hartmann, B. L., Geley, S., and Kofler, R. (2001) The Cell Cycle Inhibitor p16/Ink4a Sensitizes Lymphoblastic Leukemia Cells to Apoptosis by Physiologic Glucocorticoid Levels. J. Biol. Chem., 276, 10984-10989.

Ruefli, A. A., Ausserlechner, M. J., Bernhard, D., Sutton, V. R., Tainton, K., Kofler, R., Smyth, M. J., Johnstone, R. W. (2001) The Histone Deacetylase Inhibitor and Chemotherapeutic Agent Suberoylanilide Hydroxamic Acid (SAHA) Induces a Cell-death Pathway Characterized by Cleavage of Bid and Production of Reactive Oxygen Species.  PNAS, 18, 10833-10838.

Tonko, M., Ausserlechner, M. J., Bernhard, D., Helmberg, A., and Kofler, R. (2001). Gene Expression Profiling of Proliferating Versus G1/G0 Arrested Human Leukemia Cells Suggests a Mechanism For Glucocorticoid-induced Apoptosis. The FASEB Journal, 15, 693-699.

Larcher, C., Gasser, A., Hattmannstorfer, R., Obexer, P., Fürhapter, C., Fritsch, P., and Sepp, N. (2001) Interaction of HSV-1 infected peripheral blood mononuclear cells with cultered dermal microvascular endothelial cells: a potential model for the pathogenesis of HSV-1 induced erythema multiforme. J. Invest.Dermatol.116(1): 150-156   

Bernhard, D., Tinhofer, I, Tonko, M., Hübl, H, Ausserlechner, M. J., Greil, R, Kofler, R., and Csordas, A.(2000). Resveratrol Causes Arrest in the S-phase prior to Fas-independent Apoptosis in CEM-C7H2 Acute Leukemia Cells. Cell Death and Differentiation, 7, 834-842.

Bernhard, D., Ausserlechner, M. J., Tonko, M., Loffler, M., Hartmann, B. L., and Kofler, R. (1999). Apoptosis Induced by the Histone Deacetylase Inhibitor Butyrate in Human Leukemic Lymphoblasts. The FASEB Journal, 13, 1991-2001.

Löffler, M., Ausserlechner, M. J., Tonko, M., Hartmann, B. L., Bernhard, D., Geley, S., and Kofler, R. (1999). C-Myc Does Not Prevent Glucocorticoid-induced Apoptosis of Human Leukemic Lymphoblasts. Oncogene, 18, 4626-4631.