Publications

Small-conductance calcium-activated potassium type 2 channels (SK2, KCa2.2) in human brain.

Willis M, Trieb M, Leitner I, Wietzorrek G, Marksteiner J, Knaus HG.

Brain Struct Funct. 2016 Jun 29. [Epub ahead of print]

Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.

Rizzi S, Knaus HG, Schwarzer C.

J Comp Neurol. 2016 Jul 1;524(10):2093-116. doi: 10.1002/cne.23934.

Small-conductance Ca2+-activated potassium type 2 channels regulate the formation of contextual fear memory.

Murthy SR, Sherrin T, Jansen C, Nijholt I, Robles M, Dolga AM, Andreotti N, Sabatier JM, Knaus HG, Penner R, Todorovic C, Blank T.

PLoS One. 2015 May 4;10(5):e0127264. doi: 10.1371/journal.pone.0127264.

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons.

Dolga AM, de Andrade A, Meissner L, Knaus HG, Höllerhage M, Christophersen P, Zischka H, Plesnila N, Höglinger GU, Culmsee C.

Cell Death Dis. 2014 Jan 16;5:e999. doi: 10.1038/cddis.2013.530.

Identification of voltage-gated K(+) channel beta 2 (Kvβ2) subunit as a novel interaction partner of the pain transducer Transient Receptor Potential Vanilloid 1 channel (TRPV1).

Bavassano C, Marvaldi L, Langeslag M, Sarg B, Lindner H, Klimaschewski L, Kress M, Ferrer-Montiel A, Knaus HG.

Biochim Biophys Acta. 2013 Dec;1833(12):3166-75. doi: 10.1016/j.bbamcr.2013.09.001.

Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants.

Chen L, Bi D, Tian L, McClafferty H, Steeb F, Ruth P, Knaus HG, Shipston MJ.

J Biol Chem. 2013 May 3;288(18):13136-44. doi: 10.1074/jbc.M113.461830.

Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.

Kaya L, Meissner B, Riedl MC, Muik M, Schwarzer C, Ferraguti F, Sarg B, Lindner H, Schweigreiter R, Knaus HG, Romanin C, Bandtlow CE.

Biochim Biophys Acta. 2013 Jun;1833(6):1421-33. doi: 10.1016/j.bbamcr.2013.02.012.

Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels.

Tian L, McClafferty H, Knaus HG, Ruth P, Shipston MJ.

J Biol Chem. 2012 Apr 27;287(18):14718-25. doi: 10.1074/jbc.M111.335547.

Control of hypothalamic-pituitary-adrenal stress axis activity by the intermediate conductance calcium-activated potassium channel, SK4.

Liang Z, Chen L, McClafferty H, Lukowski R, MacGregor D, King JT, Rizzi S, Sausbier M, McCobb DP, Knaus HG, Ruth P, Shipston MJ.

J Physiol. 2011 Dec 15;589(Pt 24):5965-86. doi: 10.1113/jphysiol.2011.219378.

10.

rKv1.2 overexpression in the central medial thalamic area decreases caffeine-induced arousal.

Cazzin C, Piccoli L, Massagrande M, Garbati N, Michielin F, Knaus HG, Ring CJ, Morrison AD, Merlo-Pich E, Rovo Z, Astori S, Lüthi A, Corti C, Corsi M.

Genes Brain Behav. 2011 Nov;10(8):817-27. doi: 10.1111/j.1601-183X.2011.00719.x.

11.

KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.

Dolga AM, Terpolilli N, Kepura F, Nijholt IM, Knaus HG, D'Orsi B, Prehn JH, Eisel UL, Plant T, Plesnila N, Culmsee C.

Cell Death Dis. 2011 Apr 21;2:e147. doi: 10.1038/cddis.2011.30.

12.

Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels.

Jeffries O, Geiger N, Rowe IC, Tian L, McClafferty H, Chen L, Bi D, Knaus HG, Ruth P, Shipston MJ.

J Biol Chem. 2010 Oct 22;285(43):33307-14. doi: 10.1074/jbc.M110.153940.

13.

Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.

Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):14950-7. doi: 10.1073/pnas.1005940107.

14.

Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats.

Oliveira MS, Skinner F, Arshadmansab MF, Garcia I, Mello CF, Knaus HG, Ermolinsky BS, Otalora LF, Garrido-Sanabria ER.

Brain Res. 2010 Aug 12;1348:187-99. doi: 10.1016/j.brainres.2010.05.095.

15.

Membrane trafficking of large conductance calcium-activated potassium channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker.

Chen L, Jeffries O, Rowe IC, Liang Z, Knaus HG, Ruth P, Shipston MJ.

J Biol Chem. 2010 Jul 23;285(30):23265-75. doi: 10.1074/jbc.M110.139758.

16.

L-type calcium channel CaV 1.2 in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) mutations.

Willis M, Kaufmann WA, Wietzorrek G, Hutter-Paier B, Moosmang S, Humpel C, Hofmann F, Windisch M, Knaus HG, Marksteiner J.

J Alzheimers Dis. 2010;20(4):1167-80. doi: 10.3233/JAD-2010-091117.

17.

Large-conductance calcium-activated potassium channels in purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains.

Kaufmann WA, Ferraguti F, Fukazawa Y, Kasugai Y, Shigemoto R, Laake P, Sexton JA, Ruth P, Wietzorrek G, Knaus HG, Storm JF, Ottersen OP.

J Comp Neurol. 2009 Jul 10;515(2):215-30. doi: 10.1002/cne.22066.

18.

Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels.

Tian L, Jeffries O, McClafferty H, Molyvdas A, Rowe IC, Saleem F, Chen L, Greaves J, Chamberlain LH, Knaus HG, Ruth P, Shipston MJ.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):21006-11. doi: 10.1073/pnas.0806700106.

19.

TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels.

Dolga AM, Granic I, Blank T, Knaus HG, Spiess J, Luiten PG, Eisel UL, Nijholt IM.

J Neurochem. 2008 Nov;107(4):1158-67. doi: 10.1111/j.1471-4159.2008.05701.x.

20.

Chromogranin B and Secretogranin II in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations and in Alzheimer patients.

Willis M, Prokesch M, Hutter-Paier B, Windisch M, Stridsberg M, Mahata SK, Kirchmair R, Wietzorrek G, Knaus HG, Jellinger K, Humpel C, Marksteiner J.

J Alzheimers Dis. 2008 Mar;13(2):123-35.

21.

Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.

Pacheco Otalora LF, Hernandez EF, Arshadmansab MF, Francisco S, Willis M, Ermolinsky B, Zarei M, Knaus HG, Garrido-Sanabria ER.

Brain Res. 2008 Mar 20;1200:116-31. doi: 10.1016/j.brainres.2008.01.017.

22.

Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia.

Derfuss T, Segerer S, Herberger S, Sinicina I, Hüfner K, Ebelt K, Knaus HG, Steiner I, Meinl E, Dornmair K, Arbusow V, Strupp M, Brandt T, Theil D.

Brain Pathol. 2007 Oct;17(4):389-98.

23.

Hypothalamic-pituitary-adrenal axis hyporesponsiveness to restraint stress in mice deficient for large-conductance calcium- and voltage-activated potassium (BK) channels.

Brunton PJ, Sausbier M, Wietzorrek G, Sausbier U, Knaus HG, Russell JA, Ruth P, Shipston MJ.

Endocrinology. 2007 Nov;148(11):5496-506.

24.

Endocytic trafficking signals in KCNMB2 regulate surface expression of a large conductance voltage and Ca(2+)-activated K+ channel.

Zarei MM, Song M, Wilson RJ, Cox N, Colom LV, Knaus HG, Stefani E, Toro L.

Neuroscience. 2007 Jun 15;147(1):80-9.

25.

Localization and expression of substance P in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations.

Willis M, Hutter-Paier B, Wietzorrek G, Windisch M, Humpel C, Knaus HG, Marksteiner J.

Brain Res. 2007 Apr 27;1143:199-207.

26.

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.

Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17414-9.

27.

BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling.

Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler B.

Science. 2006 Oct 27;314(5799):615-20.

28.

A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin.

Tian L, Chen L, McClafferty H, Sailer CA, Ruth P, Knaus HG, Shipston MJ.

FASEB J. 2006 Dec;20(14):2588-90.

29.

Immunolocalization of BK channels in hippocampal pyramidal neurons.

Sailer CA, Kaufmann WA, Kogler M, Chen L, Sausbier U, Ottersen OP, Ruth P, Shipston MJ, Knaus HG.

Eur J Neurosci. 2006 Jul;24(2):442-54.

30.

Increased large conductance calcium-activated potassium (BK) channel expression accompanied by STREX variant downregulation in the developing mouse CNS.

MacDonald SH, Ruth P, Knaus HG, Shipston MJ.

BMC Dev Biol. 2006 Jul 27;6:37.

31.

A high-capacity membrane potential FRET-based assay for NaV1.8 channels.

Liu CJ, Priest BT, Bugianesi RM, Dulski PM, Felix JP, Dick IE, Brochu RM, Knaus HG, Middleton RE, Kaczorowski GJ, Slaughter RS, Garcia ML, Köhler MG.

Assay Drug Dev Technol. 2006 Feb;4(1):37-48.

32.

The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.

Schulte U, Thumfart JO, Klöcker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B.

Neuron. 2006 Mar 2;49(5):697-706.

33.

Ca2+ -activated K+ channels of the BK-type in the mouse brain.

Sausbier U, Sausbier M, Sailer CA, Arntz C, Knaus HG, Neuhuber W, Ruth P.

Histochem Cell Biol. 2006 Jun;125(6):725-41.

34.

Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing.

Chen L, Tian L, MacDonald SH, McClafferty H, Hammond MS, Huibant JM, Ruth P, Knaus HG, Shipston MJ.

J Biol Chem. 2005 Sep 30;280(39):33599-609.

35.

The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain.

Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA.

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11094-9.

36.

Role of the C-terminus of the high-conductance calcium-activated potassium channel in channel structure and function.

Schmalhofer WA, Sanchez M, Dai G, Dewan A, Secades L, Hanner M, Knaus HG, McManus OB, Kohler M, Kaczorowski GJ, Garcia ML.

Biochemistry. 2005 Aug 2;44(30):10135-44.

37.

Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice.

Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou XB, Sausbier U, Feil S, Kamm S, Essin K, Sailer CA, Abdullah U, Krippeit-Drews P, Feil R, Hofmann F, Knaus HG, Kenyon C, Shipston MJ, Storm JF, Neuhuber W, Korth M, Schubert R, Gollasch M, Ruth P.

Circulation. 2005 Jul 5;112(1):60-8.

38.

A novel isoform of SK2 assembles with other SK subunits in mouse brain.

Strassmaier T, Bond CT, Sailer CA, Knaus HG, Maylie J, Adelman JP.

J Biol Chem. 2005 Jun 3;280(22):21231-6.

39.

Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase.

Tian L, Coghill LS, McClafferty H, MacDonald SH, Antoni FA, Ruth P, Knaus HG, Shipston MJ.

Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11897-902.

40.

K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity.

Wulff H, Knaus HG, Pennington M, Chandy KG.

J Immunol. 2004 Jul 15;173(2):776-86.

41.

Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain.

Sailer CA, Kaufmann WA, Marksteiner J, Knaus HG.

Mol Cell Neurosci. 2004 Jul;26(3):458-69.

42.

An endoplasmic reticulum trafficking signal prevents surface expression of a voltage- and Ca2+-activated K+ channel splice variant.

Zarei MM, Eghbali M, Alioua A, Song M, Knaus HG, Stefani E, Toro L.

Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10072-7.

43.

Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency.

Sausbier M, Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, Sausbier U, Sailer CA, Feil R, Hofmann F, Korth M, Shipston MJ, Knaus HG, Wolfer DP, Pedroarena CM, Storm JF, Ruth P.

Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9474-8.

44.

Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia.

Shakkottai VG, Chou CH, Oddo S, Sailer CA, Knaus HG, Gutman GA, Barish ME, LaFerla FM, Chandy KG.

J Clin Invest. 2004 Feb;113(4):582-90.

45.

Subcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heart.

Rasmussen HB, Møller M, Knaus HG, Jensen BS, Olesen SP, Jørgensen NK.

Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1300-9.

46.

A radiolabeled peptide ligand of the hERG channel, [125I]-BeKm-1.

Angelo K, Korolkova YV, Grunnet M, Grishin EV, Pluzhnikov KA, Klaerke DA, Knaus HG, Møller M, Olesen SP.

Pflugers Arch. 2003 Oct;447(1):55-63.

47.

Localization of Ca2+ -activated big-conductance K+ channels in rabbit distal colon.

Hay-Schmidt A, Grunnet M, Abrahamse SL, Knaus HG, Klaerke DA.

Pflugers Arch. 2003 Apr;446(1):61-8.

48.

The small conductance Ca2+-activated K+ channel SK3 is localized in nerve terminals of excitatory synapses of cultured mouse hippocampal neurons.

Obermair GJ, Kaufmann WA, Knaus HG, Flucher BE.

Eur J Neurosci. 2003 Feb;17(4):721-31.

49.

Regional differences in distribution and functional expression of small-conductance Ca2+-activated K+ channels in rat brain.

Sailer CA, Hu H, Kaufmann WA, Trieb M, Schwarzer C, Storm JF, Knaus HG.

J Neurosci. 2002 Nov 15;22(22):9698-707.

50.

Synthesis, characterization, and application of cy-dye- and alexa-dye-labeled hongotoxin(1) analogues. The first high affinity fluorescence probes for voltage-gated K+ channels.

Pragl B, Koschak A, Trieb M, Obermair G, Kaufmann WA, Gerster U, Blanc E, Hahn C, Prinz H, Schütz G, Darbon H, Gruber HJ, Knaus HG.

Bioconjug Chem. 2002 May-Jun;13(3):416-25.

51.

Ultrasensitive pharmacological characterisation of the voltage-gated potassium channel K(V)1.3 studied by single-molecule fluorescence microscopy.

Freudenthaler G, Axmann M, Schindler H, Pragl B, Knaus HG, Schütz GJ.

Histochem Cell Biol. 2002 Mar;117(3):197-202.

52.

Presynaptic Ca2+-activated K+ channels in glutamatergic hippocampal terminals and their role in spike repolarization and regulation of transmitter release.

Hu H, Shao LR, Chavoshy S, Gu N, Trieb M, Behrens R, Laake P, Pongs O, Knaus HG, Ottersen OP, Storm JF.

J Neurosci. 2001 Dec 15;21(24):9585-97.

53.

Potassium channels regulate tone in rat pulmonary veins.

Michelakis ED, Weir EK, Wu X, Nsair A, Waite R, Hashimoto K, Puttagunta L, Knaus HG, Archer SL.

Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1138-47.

54.

Developmental expression of the small-conductance Ca(2+)-activated potassium channel SK2 in the rat retina.

Klöcker N, Oliver D, Ruppersberg JP, Knaus HG, Fakler B.

Mol Cell Neurosci. 2001 Mar;17(3):514-20.

55.

Anomalous fluorescence enhancement of Cy3 and cy3.5 versus anomalous fluorescence loss of Cy5 and Cy7 upon covalent linking to IgG and noncovalent binding to avidin.

Gruber HJ, Hahn CD, Kada G, Riener CK, Harms GS, Ahrer W, Dax TG, Knaus HG.

Bioconjug Chem. 2000 Sep-Oct;11(5):696-704.

56.

Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.

Bond CT, Sprengel R, Bissonnette JM, Kaufmann WA, Pribnow D, Neelands T, Storck T, Baetscher M, Jerecic J, Maylie J, Knaus HG, Seeburg PH, Adelman JP.

Science. 2000 Sep 15;289(5486):1942-6.

57.

Generating a high affinity scorpion toxin receptor in KcsA-Kv1.3 chimeric potassium channels.

Legros C, Pollmann V, Knaus HG, Farrell AM, Darbon H, Bougis PE, Martin-Eauclaire MF, Pongs O.

J Biol Chem. 2000 Jun 2;275(22):16918-24.

58.

High affinity interaction of mibefradil with voltage-gated calcium and sodium channels.

Eller P, Berjukov S, Wanner S, Huber I, Hering S, Knaus HG, Toth G, Kimball SD, Striessnig J.

Br J Pharmacol. 2000 Jun;130(3):669-77.

59.

Preparation of thiol-reactive Cy5 derivatives from commercial Cy5 succinimidyl ester.

Gruber HJ, Kada G, Pragl B, Riener C, Hahn CD, Harms GS, Ahrer W, Dax TG, Hohenthanner K, Knaus HG.

Bioconjug Chem. 2000 Mar-Apr;11(2):161-6.

60.

WIN 17317-3, a new high-affinity probe for voltage-gated sodium channels.

Wanner SG, Glossmann H, Knaus HG, Baker R, Parsons W, Rupprecht KM, Brochu R, Cohen CJ, Schmalhofer W, Smith M, Warren V, Garcia ML, Kaczorowski GJ.

Biochemistry. 1999 Aug 24;38(34):11137-46.

61.

Quantification and distribution of Ca(2+)-activated maxi K(+) channels in rabbit distal colon.

Grunnet M, Knaus HG, Solander C, Klaerke DA.

Am J Physiol. 1999 Jul;277(1 Pt 1):G22-30.

62.

High-conductance calcium-activated potassium channels in rat brain: pharmacology, distribution, and subunit composition.

Wanner SG, Koch RO, Koschak A, Trieb M, Garcia ML, Kaczorowski GJ, Knaus HG.

Biochemistry. 1999 Apr 27;38(17):5392-400.

63.

Scorpion toxins as tools for studying potassium channels.

Garcia ML, Hanner M, Knaus HG, Slaughter R, Kaczorowski GJ.

Methods Enzymol. 1999;294:624-39. Review.

64.

Purification and functional reconstitution of high-conductance calcium-activated potassium channel from smooth muscle.

Garcia ML, Giangiacomo KM, Hanner M, Knaus HG, McManus OB, Schmalhofer WA, Kaczorowski GJ.

Methods Enzymol. 1999;294:274-87. No abstract available.

65.

The beta subunit of the high conductance calcium-activated potassium channel. Identification of residues involved in charybdotoxin binding.

Hanner M, Vianna-Jorge R, Kamassah A, Schmalhofer WA, Knaus HG, Kaczorowski GJ, Garcia ML.

J Biol Chem. 1998 Jun 26;273(26):16289-96.

66.

Glucocorticoid regulation of calcium-activated potassium channels mediated by serine/threonine protein phosphatase.

Tian L, Knaus HG, Shipston MJ.

J Biol Chem. 1998 May 29;273(22):13531-6.

67.

Margatoxin increases dopamine release in rat striatum via voltage-gated K+ channels.

Saria A, Seidl CV, Fischer HS, Koch RO, Telser S, Wanner SG, Humpel C, Garcia ML, Knaus HG.

Eur J Pharmacol. 1998 Feb 19;343(2-3):193-200.

68.

Increased expression of Ca2+-sensitive K+ channels in the cerebral microcirculation of genetically hypertensive rats: evidence for their protection against cerebral vasospasm.

Liu Y, Hudetz AG, Knaus HG, Rusch NJ.

Circ Res. 1998 Apr 6;82(6):729-37.

69.

Subunit composition of brain voltage-gated potassium channels determined by hongotoxin-1, a novel peptide derived from Centruroides limbatus venom.

Koschak A, Bugianesi RM, Mitterdorfer J, Kaczorowski GJ, Garcia ML, Knaus HG.

J Biol Chem. 1998 Jan 30;273(5):2639-44.

70.

Increased expression of Ca2+-sensitive K+ channels in aorta of hypertensive rats.

Liu Y, Pleyte K, Knaus HG, Rusch NJ.

Hypertension. 1997 Dec;30(6):1403-9.

71.

Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology.

Koch RO, Wanner SG, Koschak A, Hanner M, Schwarzer C, Kaczorowski GJ, Slaughter RS, Garcia ML, Knaus HG.

J Biol Chem. 1997 Oct 31;272(44):27577-81.

72.

Molecular constituents of maxi KCa channels in human coronary smooth muscle: predominant alpha + beta subunit complexes.

Tanaka Y, Meera P, Song M, Knaus HG, Toro L.

J Physiol. 1997 Aug 1;502 ( Pt 3):545-57.

73.

The beta subunit of the high-conductance calcium-activated potassium channel contributes to the high-affinity receptor for charybdotoxin.

Hanner M, Schmalhofer WA, Munujos P, Knaus HG, Kaczorowski GJ, Garcia ML.

Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2853-8.

74.

Margatoxin binds to a homomultimer of K(V)1.3 channels in Jurkat cells. Comparison with K(V)1.3 expressed in CHO cells.

Helms LM, Felix JP, Bugianesi RM, Garcia ML, Stevens S, Leonard RJ, Knaus HG, Koch R, Wanner SG, Kaczorowski GJ, Slaughter RS.

Biochemistry. 1997 Mar 25;36(12):3737-44.

75.

[125I]Iberiotoxin-D19Y/Y36F, the first selective, high specific activity radioligand for high-conductance calcium-activated potassium channels.

Koschak A, Koch RO, Liu J, Kaczorowski GJ, Reinhart PH, Garcia ML, Knaus HG.

Biochemistry. 1997 Feb 18;36(7):1943-52.

76.

Pharmacology of potassium channels.

Garcia ML, Hanner M, Knaus HG, Koch R, Schmalhofer W, Slaughter RS, Kaczorowski GJ.

Adv Pharmacol. 1997;39:425-71. Review. No abstract available.

77.

Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

Hanner M, Moebius FF, Flandorfer A, Knaus HG, Striessnig J, Kempner E, Glossmann H.

Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):8072-7.

78.

High-conductance calcium-activated potassium channels; structure, pharmacology, and function.

Kaczorowski GJ, Knaus HG, Leonard RJ, McManus OB, Garcia ML.

J Bioenerg Biomembr. 1996 Jun;28(3):255-67. Review.

79.

Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals.

Knaus HG, Schwarzer C, Koch RO, Eberhart A, Kaczorowski GJ, Glossmann H, Wunder F, Pongs O, Garcia ML, Sperk G.

J Neurosci. 1996 Feb 1;16(3):955-63.

80.

Functional reconstitution of the large-conductance, calcium-activated potassium channel purified from bovine aortic smooth muscle.

Giangiacomo KM, Garcia-Calvo M, Knaus HG, Mullmann TJ, Garcia ML, McManus O.

Biochemistry. 1995 Dec 5;34(48):15849-62.

81.

[125I]margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mammalian brain.

Knaus HG, Koch RO, Eberhart A, Kaczorowski GJ, Garcia ML, Slaughter RS.

Biochemistry. 1995 Oct 17;34(41):13627-34.

82.

Characterization of tissue-expressed alpha subunits of the high conductance Ca(2+)-activated K+ channel.

Knaus HG, Eberhart A, Koch RO, Munujos P, Schmalhofer WA, Warmke JW, Kaczorowski GJ, Garcia ML.

J Biol Chem. 1995 Sep 22;270(38):22434-9.

83.

Cross-linking of charybdotoxin to high-conductance calcium-activated potassium channels: identification of the covalently modified toxin residue.

Munujos P, Knaus HG, Kaczorowski GJ, Garcia ML.

Biochemistry. 1995 Aug 29;34(34):10771-6.

84.

Charybdotoxin and its effects on potassium channels.

Garcia ML, Knaus HG, Munujos P, Slaughter RS, Kaczorowski GJ.

Am J Physiol. 1995 Jul;269(1 Pt 1):C1-10. Review.

85.

Purification and amino-terminal sequencing of the high affinity phenylalkylamine Ca2+ antagonist binding protein from guinea pig liver endoplasmic reticulum.

Moebius FF, Hanner M, Knaus HG, Weber F, Striessnig J, Glossmann H.

J Biol Chem. 1994 Nov 18;269(46):29314-20.

: 86.

Pharmacology and structure of high conductance calcium-activated potassium channels.

Knaus HG, Eberhart A, Glossmann H, Munujos P, Kaczorowski GJ, Garcia ML.

Cell Signal. 1994 Nov;6(8):861-70. Review. No abstract available.

87.

Covalent attachment of charybdotoxin to the beta-subunit of the high conductance Ca(2+)-activated K+ channel. Identification of the site of incorporation and implications for channel topology.

Knaus HG, Eberhart A, Kaczorowski GJ, Garcia ML.

J Biol Chem. 1994 Sep 16;269(37):23336-41.

88.

Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle.

Knaus HG, Folander K, Garcia-Calvo M, Garcia ML, Kaczorowski GJ, Smith M, Swanson R.

J Biol Chem. 1994 Jun 24;269(25):17274-8.

89.

Functional unit size of the charybdotoxin receptor in smooth muscle.

Garcia-Calvo M, Knaus HG, Garcia ML, Kaczorowski GJ, Kempner ES.

Proc Natl Acad Sci U S A. 1994 May 24;91(11):4718-22.

90.

Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels.

Knaus HG, McManus OB, Lee SH, Schmalhofer WA, Garcia-Calvo M, Helms LM, Sanchez M, Giangiacomo K, Reuben JP, Smith AB 3rd, et al.

Biochemistry. 1994 May 17;33(19):5819-28.

91.

Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels.

Knaus HG, Garcia-Calvo M, Kaczorowski GJ, Garcia ML.

J Biol Chem. 1994 Feb 11;269(6):3921-4.

92.

Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle.

Garcia-Calvo M, Knaus HG, McManus OB, Giangiacomo KM, Kaczorowski GJ, Garcia ML.

J Biol Chem. 1994 Jan 7;269(1):676-82.

93.

Heterogeneity of L-type calcium channel alpha 1 subunits: stereoselective discrimination of different populations by the novel 1,4-dihydropyridine B 874-67.

Lakitsch M, Knaus HG, Topar G, Romanin C, Boer R, Flockerzi D, Striessnig J, Schindler H, Hoeltje HD, Glossmann H.

Mol Pharmacol. 1993 Feb;43(2):293-301.

94.

In vivo labeling of L-type Ca2+ channels by fluorescent dihydropyridines: evidence for a functional, extracellular heparin-binding site.

Knaus HG, Moshammer T, Friedrich K, Kang HC, Haugland RP, Glossman H.

Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3586-90.

95.

A unique fluorescent phenylalkylamine probe for L-type Ca2+ channels. Coupling of phenylalkylamine receptors to Ca2+ and dihydropyridine binding sites.

Knaus HG, Moshammer T, Kang HC, Haugland RP, Glossmann H.

J Biol Chem. 1992 Feb 5;267(4):2179-89.

96.

[35S]sadopine, a novel high affinity, high specific activity, L-type Ca2+ channel probe: characterization of two equipotent diastereomers with opposite allosteric properties.

Knaus HG, Striessnig J, Hering S, Marrer S, Schwenner E, Höltje HD, Glossmann H.

Mol Pharmacol. 1992 Feb;41(2):298-307.

97.

Complex allosteric interaction of heparin with neurokinin-1 receptors.

Knaus GA, Knaus HG, Saria A.

Eur J Pharmacol. 1991 Jul 12;207(3):267-70.

98.

Positive heterotropic allosteric regulators of dihydropyridine binding increase the Ca2+ affinity of the L-type Ca2+ channel. Stereoselective reversal by the novel Ca2+ antagonist BM 20.1140.

Staudinger R, Knaus HG, Glossmann H.

J Biol Chem. 1991 Jun 15;266(17):10787-95.

99.

Calcium channels from Cyprinus carpio skeletal muscle.

Grabner M, Friedrich K, Knaus HG, Striessnig J, Scheffauer F, Staudinger R, Koch WJ, Schwartz A, Glossmann H.

Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):727-31.

100.

Neurokinin-1 receptors in the human eye. Characterization and autoradiographic distribution.

Kieselbach GF, Ragaut R, Knaus HG, König P, Saria A, Wiedermann CJ.

Ann N Y Acad Sci. 1991;632:466-7. No abstract available.

101.

Allosteric interaction of heparin with NK-1 receptors in rat striatal membranes.

Knaus GA, Knaus HG, Saria A.

Ann N Y Acad Sci. 1991;632:422-5. No abstract available.

102.

Heparin binds with high affinity to voltage-dependent L-type Ca2+ channels. Evidence for an agonistic action.

Knaus HG, Scheffauer F, Romanin C, Schindler HG, Glossmann H.

J Biol Chem. 1990 Jul 5;265(19):11156-66.

103.

Autoradiographic analysis of binding sites for 125I-Bolton-Hunter-substance P in the human eye.

Kieselbach GF, Ragaut R, Knaus HG, König P, Wiedermann CJ.

Peptides. 1990 Jul-Aug;11(4):655-9.

104.

Effects of haloperidol and clozapine on preprotachykinin-A messenger RNA, tachykinin tissue levels, release and neurokinin-1 receptors in the striato-nigral system.

Humpel C, Knaus GA, Auer B, Knaus HG, Haring C, Theodorsson E, Saria A.

Synapse. 1990;6(1):1-9.

105.

[3H]HOE166 defines a novel calcium antagonist drug receptor--distinct from the 1,4 dihydropyridine binding domain.

Grassegger A, Striessnig J, Weiler M, Knaus HG, Glossmann H.

Naunyn Schmiedebergs Arch Pharmacol. 1989 Dec;340(6 Pt 2):752-9.

106.

Structure of calcium channels.

Glossmann H, Striessnig J, Knaus HG, Müller J, Grassegger A, Höltje HD, Marrer S, Hymel L, Schindler HG.

Ann N Y Acad Sci. 1989;560:198-214. Review. No abstract available.

107.

Photoaffinity-labelling of the calcium-channel-associated 1,4-dihydropyridine and phenylalkylamine receptor in guinea-pig hippocampus. A 195 kDa polypeptide carries both drug receptors and has similarities to the alpha 1 subunit of the purified skeletal-muscle calcium channel.

Striessnig J, Knaus HG, Glossmann H.

Biochem J. 1988 Jul 1;253(1):39-47.

108.

Evidence for a distinct Ca2+ antagonist receptor for the novel benzothiazinone compound HOE 166.

Striessnig J, Meusburger E, Grabner M, Knaus HG, Glossmann H, Kaiser J, Schölkens B, Becker R, Linz W, Henning R.

Naunyn Schmiedebergs Arch Pharmacol. 1988 Mar;337(3):331-40.

109.

Neurotoxic aminoglycoside antibiotics are potent inhibitors of [125I]-Omega-Conotoxin GVIA binding to guinea-pig cerebral cortex membranes.

Knaus HG, Striessnig J, Koza A, Glossmann H.

Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):583-6.

110.

Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations.

Vaghy PL, Striessnig J, Miwa K, Knaus HG, Itagaki K, McKenna E, Glossmann H, Schwartz A.

J Biol Chem. 1987 Oct 15;262(29):14337-42.

111.

Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel.

Striessnig J, Knaus HG, Grabner M, Moosburger K, Seitz W, Lietz H, Glossmann H.

FEBS Lett. 1987 Feb 23;212(2):247-53.

Institut für Molekulare & Zelluläre Pharmakologie