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Renal Epithelial Cell Physiology - Jennings Team Publications

 

Research Articles

[Link to Pubmed] 

  1. Herwig, R., Gmuender, H., Corvi, R., Bloch, K.M., Brandenburg, A., Castell, J., Ceelen, L., Chesne, C., Doktorova, T.Y., Jennen, D., Jennings, P., Limonciel, A., Lock, E.A., McMorrow, T., Phrakonkham, P., Radford, R., Slattery, C., Stierum, R., Vilardell, M., Wittenberger, T., Yildirimman, R., Ryan, M., Rogiers, V., and Kleinjans, J., Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective. Arch Toxicol, 2016. 90(9): p. 2215-29. https://www.ncbi.nlm.nih.gov/pubmed/26525393
  2. Hammond, T.G., Moes, S., Youhanna, S., Jennings, P., Devuyst, O., Odermatt, A., and Jeno, P., Development and characterization of a pseudo multiple reaction monitoring method for the quantification of human uromodulin in urine. Bioanalysis, 2016. 8(12): p. 1279-96. http://www.ncbi.nlm.nih.gov/pubmed/27187191
  3. Fernando, R.N., Chaudhari, U., Escher, S.E., Hengstler, J.G., Hescheler, J., Jennings, P., Keun, H.C., Kleinjans, J.C., Kolde, R., Kollipara, L., Kopp-Schneider, A., Limonciel, A., Nemade, H., Nguemo, F., Peterson, H., Prieto, P., Rodrigues, R.M., Sachinidis, A., Schafer, C., Sickmann, A., Spitkovsky, D., Stober, R., van Breda, S.G., van de Water, B., Vivier, M., Zahedi, R.P., Vinken, M., and Rogiers, V., "Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015. Arch Toxicol, 2016. 90(6): p. 1529-39. http://www.ncbi.nlm.nih.gov/pubmed/27129694
  4. Ranninger, C., Schmidt, L.E., Rurik, M., Limonciel, A., Jennings, P., Kohlbacher, O., and Huber, C.G., Improving global feature detectabilities through scan range splitting for untargeted metabolomics by high-performance liquid chromatography-Orbitrap mass spectrometry. Anal Chim Acta, 2016. 930: p. 13-22. http://www.ncbi.nlm.nih.gov/pubmed/27265900
  5. Yoon, M., Adeleye, Y., Clewell, R., Jennings, P., and Whelan, M., Moving Beyond Prioritization Toward True In Vitro Safety Assessment. Applied In Vitro Toxicology, 2016. 2(2): p. 67-73. http://dx.doi.org/10.1089/aivt.2016.29005.rtl
  6. Stacey, G.N., Coecke, S., Price, A.B., Healy, L., Jennings, P., Wilmes, A., Pinset, C., Ingelman-Sundberg, M., Louisse, J., Haupt, S., Kidd, D., Robitski, A., Jahnke, H.G., Lemaitre, G., and Myatt, G., Ensuring the Quality of Stem Cell-Derived In Vitro Models for Toxicity Testing. Adv Exp Med Biol, 2016. 856: p. 259-297. http://www.ncbi.nlm.nih.gov/pubmed/27671727
  7. Jennings, P., "The future of in vitro toxicology". Toxicol In Vitro, 2015. 29(6): p. 1217-21. http://www.ncbi.nlm.nih.gov/pubmed/25450745
  8. Herwig, R., Gmuender, H., Corvi, R., Bloch, K.M., Brandenburg, A., Castell, J., Ceelen, L., Chesne, C., Doktorova, T.Y., Jennen, D., Jennings, P., Limonciel, A., Lock, E.A., McMorrow, T., Phrakonkham, P., Radford, R., Slattery, C., Stierum, R., Vilardell, M., Wittenberger, T., Yildirimman, R., Ryan, M., Rogiers, V., and Kleinjans, J., Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective. Arch Toxicol, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26525393
  9. Suter-Dick, L., Alves, P.M., Blaauboer, B.J., Bremm, K.D., Brito, C., Coecke, S., Flick, B., Fowler, P., Hescheler, J., Ingelman-Sundberg, M., Jennings, P., Kelm, J.M., Manou, I., Mistry, P., Moretto, A., Roth, A., Stedman, D., van de Water, B., and Beilmann, M., Stem cell-derived systems in toxicology assessment. Stem Cells Dev, 2015. 24(11): p. 1284-96. http://www.ncbi.nlm.nih.gov/pubmed/25675366
  10. Ranninger, C., Rurik, M., Limonciel, A., Ruzek, S., Reischl, R., Wilmes, A., Jennings, P., Hewitt, P., Dekant, W., Kohlbacher, O., and Huber, C.G., Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline. J Biol Chem, 2015. 290(31): p. 19121-32. http://www.ncbi.nlm.nih.gov/pubmed/26055719
  11. Jennings, P., Crean, D., Aschauer, L., Limonciel, A., Moenks, K., Kern, G., Hewitt, P., Lhotta, K., Lukas, A., Wilmes, A., and Leonard, M.O., Interleukin-19 as a translational indicator of renal injury. Arch Toxicol, 2015. 89(1): p. 101-6. http://www.ncbi.nlm.nih.gov/pubmed/24714768
  12. Wilmes, A., Bielow, C., Ranninger, C., Bellwon, P., Aschauer, L., Limonciel, A., Chassaigne, H., Kristl, T., Aiche, S., Huber, C.G., Guillou, C., Hewitt, P., Leonard, M.O., Dekant, W., Bois, F., and Jennings, P., Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro, 2015. 30(1 Pt A): p. 117-127. http://www.ncbi.nlm.nih.gov/pubmed/25450742
  13. Pfaller, W., Prieto, P., Dekant, W., Jennings, P., and Blaauboer, B.J., The Predict-IV project: Towards predictive toxicology using in vitro techniques. Toxicol In Vitro, 2015. 30(1 Pt A): p. 1-3. http://www.ncbi.nlm.nih.gov/pubmed/26653009
  14. Mueller, S.O., Dekant, W., Jennings, P., Testai, E., and Bois, F., Comprehensive summary - Predict-IV: A systems toxicology approach to improve pharmaceutical drug safety testing. Toxicol In Vitro, 2015. 30(1 Pt A): p. 4-6. http://www.ncbi.nlm.nih.gov/pubmed/25450741
  15. Limonciel, A., Moenks, K., Stanzel, S., Truisi, G.L., Parmentier, C., Aschauer, L., Wilmes, A., Richert, L., Hewitt, P., Mueller, S.O., Lukas, A., Kopp-Schneider, A., Leonard, M.O., and Jennings, P., Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro, 2015. 30(1 Pt A): p. 7-18. http://www.ncbi.nlm.nih.gov/pubmed/25596134
  16. Crean, D., Bellwon, P., Aschauer, L., Limonciel, A., Moenks, K., Hewitt, P., Schmidt, T., Herrgen, K., Dekant, W., Lukas, A., Bois, F., Wilmes, A., Jennings, P., and Leonard, M.O., Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing. Toxicol In Vitro, 2015. 30(1 Pt A): p. 128-137. http://www.ncbi.nlm.nih.gov/pubmed/25536518
  17. Bellwon, P., Truisi, G.L., Bois, F.Y., Wilmes, A., Schmidt, T., Savary, C.C., Parmentier, C., Hewitt, P.G., Schmal, O., Josse, R., Richert, L., Guillouzo, A., Mueller, S.O., Jennings, P., Testai, E., and Dekant, W., Kinetics and dynamics of cyclosporine A in three hepatic cell culture systems. Toxicol In Vitro, 2015. 30(1 Pt A): p. 62-78. http://www.ncbi.nlm.nih.gov/pubmed/26193170
  18. Bellwon, P., Culot, M., Wilmes, A., Schmidt, T., Zurich, M.G., Schultz, L., Schmal, O., Gramowski-Voss, A., Weiss, D.G., Jennings, P., Bal-Price, A., Testai, E., and Dekant, W., Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood-brain barrier. Toxicol In Vitro, 2015. 30(1 Pt A): p. 166-175. http://www.ncbi.nlm.nih.gov/pubmed/25683621
  19. Aschauer, L., Limonciel, A., Wilmes, A., Stanzel, S., Kopp-Schneider, A., Hewitt, P., Lukas, A., Leonard, M.O., Pfaller, W., and Jennings, P., Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study. Toxicol In Vitro, 2015. 30(1 Pt A): p. 106-116. http://www.ncbi.nlm.nih.gov/pubmed/25450743
  20. Aschauer, L., Carta, G., Vogelsang, N., Schlatter, E., and Jennings, P., Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1. Toxicol In Vitro, 2015. 30(1 Pt A): p. 95-105. http://www.ncbi.nlm.nih.gov/pubmed/25500123
  21. Bloch, K.M., Yaqoob, N., Sharma, S., Evans, A., Aschauer, L., Radford, R., Jennings, P., Ryan, M.P., Van Delft, J.H.M., and Lock, E.A., Transcriptomic alterations induced by Monuron in rat and human renal proximal tubule cells in vitro and comparison to rat renal-cortex in vivo. Toxicology Research, 2015. 4(2): p. 423-431. <Go to ISI>://WOS:000350552900023
  22. Wilmes, A., Aschauer, L., Limonciel, A., Pfaller, W., and Jennings, P., Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol, 2014. 279(2): p. 163-72. http://www.ncbi.nlm.nih.gov/pubmed/24907557
  23. Limonciel, A. and Jennings, P., A review of the evidence that ochratoxin A is an Nrf2 inhibitor: implications for nephrotoxicity and renal carcinogenicity. Toxins (Basel), 2014. 6(1): p. 371-9. http://www.ncbi.nlm.nih.gov/pubmed/24448208
  24. Jennings, P., Schwarz, M., Landesmann, B., Maggioni, S., Goumenou, M., Bower, D., Leonard, M.O., and Wiseman, J.S., SEURAT-1 liver gold reference compounds: a mechanism-based review. Arch Toxicol, 2014. 88(12): p. 2099-133. http://www.ncbi.nlm.nih.gov/pubmed/25395007
  25. Sengoelge, G., Winnicki, W., Kupczok, A., von Haeseler, A., Schuster, M., Pfaller, W., Jennings, P., Weltermann, A., Blake, S., and Sunder-Plassmann, G., A SAGE based approach to human glomerular endothelium: defining the transcriptome, finding a novel molecule and highlighting endothelial diversity. BMC Genomics, 2014. 15(1): p. 725. http://www.ncbi.nlm.nih.gov/pubmed/25163811
  26. Kern, G., Mair, S.M., Noppert, S.J., Jennings, P., Schramek, H., Rudnicki, M., Mueller, G.A., Mayer, G., and Koppelstaetter, C., Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling. PLoS One, 2014. 9(5): p. e96377. http://www.ncbi.nlm.nih.gov/pubmed/24816588
  27. Hamon, J., Jennings, P., and Bois, F.Y., Systems biology modeling of omics data: effect of cyclosporine a on the Nrf2 pathway in human renal cells. BMC Syst Biol, 2014. 8: p. 76. http://www.ncbi.nlm.nih.gov/pubmed/24964791
  28. Wilmes, A., Leonard, M.O., and Jennings, P., Nrf2 inducibility of aldo-keto reductases. Toxicol Lett, 2013. 221(1): p. 39. http://www.ncbi.nlm.nih.gov/pubmed/23732362
  29. Aschauer, L., Gruber, L.N., Pfaller, W., Limonciel, A., Athersuch, T.J., Cavill, R., Khan, A., Gstraunthaler, G., Grillari, J., Grillari, R., Hewitt, P., Leonard, M.O., Wilmes, A., and Jennings, P., Delineation of the key aspects in the regulation of epithelial monolayer formation. Mol Cell Biol, 2013. 33(13): p. 2535-50. http://www.ncbi.nlm.nih.gov/pubmed/23608536
  30. Jennings, P., Limonciel, A., Felice, L., and Leonard, M.O., An overview of transcriptional regulation in response to toxicological insult. Arch Toxicol, 2013. 87(1): p. 49-72. http://www.ncbi.nlm.nih.gov/pubmed/22926699
  31. Jennings, P., Stress response pathways, toxicity pathways and adverse outcome pathways. Arch Toxicol, 2013. 87(1): p. 13-4. http://www.ncbi.nlm.nih.gov/pubmed/23149676
  32. Wilmes, A., Limonciel, A., Aschauer, L., Moenks, K., Bielow, C., Leonard, M.O., Hamon, J., Carpi, D., Ruzek, S., Handler, A., Schmal, O., Herrgen, K., Bellwon, P., Burek, C., Truisi, G.L., Hewitt, P., Di Consiglio, E., Testai, E., Blaauboer, B.J., Guillou, C., Huber, C.G., Lukas, A., Pfaller, W., Mueller, S.O., Bois, F.Y., Dekant, W., and Jennings, P., Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress. J Proteomics, 2013. 79: p. 180-94. http://www.ncbi.nlm.nih.gov/pubmed/23238060
  33. Crean, D., Felice, L., Pierre, P., Jennings, P., and Leonard, M.O., Inhibition of protein translation as a mechanism of acidotic pH protection against ischaemic injury through inhibition of CREB mediated tRNA synthetase expression. Exp Cell Res, 2013. 319(20): p. 3116-27. http://www.ncbi.nlm.nih.gov/pubmed/23896026
  34. Wiesinger, M., Mayer, B., Jennings, P., and Lukas, A., Comparative analysis of perturbed molecular pathways identified in in vitro and in vivo toxicology studies. Toxicol In Vitro, 2012. 26(6): p. 956-62. http://www.ncbi.nlm.nih.gov/pubmed/22515967
  35. Limonciel, A., Wilmes, A., Aschauer, L., Radford, R., Bloch, K.M., McMorrow, T., Pfaller, W., van Delft, J.H., Slattery, C., Ryan, M.P., Lock, E.A., and Jennings, P., Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells. Arch Toxicol, 2012. 86(11): p. 1741-51. http://www.ncbi.nlm.nih.gov/pubmed/22760423
  36. Crean, D., Felice, L., Taylor, C.T., Rabb, H., Jennings, P., and Leonard, M.O., Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion. Mol Cell Biochem, 2012. 366(1-2): p. 231-8. http://www.ncbi.nlm.nih.gov/pubmed/22460831
  37. Radford, R., Slattery, C., Jennings, P., Blacque, O., Pfaller, W., Gmuender, H., Van Delft, J., Ryan, M.P., and McMorrow, T., Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle. Am J Physiol Renal Physiol, 2012. 302(8): p. F905-16. http://www.ncbi.nlm.nih.gov/pubmed/22262483
  38. Jennings, P., Weiland, C., Limonciel, A., Bloch, K.M., Radford, R., Aschauer, L., McMorrow, T., Wilmes, A., Pfaller, W., Ahr, H.J., Slattery, C., Lock, E.A., Ryan, M.P., and Ellinger-Ziegelbauer, H., Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model. Arch Toxicol, 2012. 86(4): p. 571-89. http://www.ncbi.nlm.nih.gov/pubmed/22124623
  39. Bloch, K.M., Yaqoob, N., Evans, A., Radford, R., Jennings, P., Boei, J.J.W.A., McMorrow, T., Slattery, C., Ryan, M.P., Gmuender, H., van Delft, J.H.M., and Lock, E.A., Detection of genotoxic and non-genotoxic renal carcinogens in vitro in NRK-52E cells using a transcriptomics approach. Toxicology Research, 2012. 1(3): p. 211-219. <Go to ISI>://WOS:000315733500007
  40. Forti, E., Salovaara, S., Cetin, Y., Bulgheroni, A., Tessadri, R., Jennings, P., Pfaller, W., and Prieto, P., In vitro evaluation of the toxicity induced by nickel soluble and particulate forms in human airway epithelial cells. Toxicol In Vitro, 2011. 25(2): p. 454-61. http://www.ncbi.nlm.nih.gov/pubmed/21111804
  41. Ellis, J.K., Athersuch, T.J., Cavill, R., Radford, R., Slattery, C., Jennings, P., McMorrow, T., Ryan, M.P., Ebbels, T.M., and Keun, H.C., Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system. Mol Biosyst, 2011. 7(1): p. 247-57. http://www.ncbi.nlm.nih.gov/pubmed/21103459
  42. Limonciel, A., Aschauer, L., Wilmes, A., Prajczer, S., Leonard, M.O., Pfaller, W., and Jennings, P., Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes. Toxicol In Vitro, 2011. 25(8): p. 1855-62. http://www.ncbi.nlm.nih.gov/pubmed/21635945
  43. Wilmes, A., Crean, D., Aydin, S., Pfaller, W., Jennings, P., and Leonard, M.O., Identification and dissection of the Nrf2 mediated oxidative stress pathway in human renal proximal tubule toxicity. Toxicol In Vitro, 2011. 25(3): p. 613-22. http://www.ncbi.nlm.nih.gov/pubmed/21172416
  44. Wemhoner, A., Jennings, P., Haller, T., Rudiger, M., and Simbruner, G., Effect of exogenous surfactants on viability and DNA synthesis in A549, immortalized mouse type II and isolated rat alveolar type II cells. BMC Pulm Med, 2011. 11: p. 11. http://www.ncbi.nlm.nih.gov/pubmed/21324208
  45. Prajczer, S., Heidenreich, U., Pfaller, W., Kotanko, P., Lhotta, K., and Jennings, P., Evidence for a role of uromodulin in chronic kidney disease progression. Nephrol Dial Transplant, 2010. 25(6): p. 1896-903. http://www.ncbi.nlm.nih.gov/pubmed/20075439
  46. Signorelli, S., Jennings, P., Leonard, M.O., and Pfaller, W., Differential effects of hypoxic stress in alveolar epithelial cells and microvascular endothelial cells. Cell Physiol Biochem, 2010. 25(1): p. 135-44. http://www.ncbi.nlm.nih.gov/pubmed/20054152
  47. Schmid, M., Prajczer, S., Gruber, L.N., Bertocchi, C., Gandini, R., Pfaller, W., Jennings, P., and Joannidis, M., Uromodulin facilitates neutrophil migration across renal epithelial monolayers. Cell Physiol Biochem, 2010. 26(3): p. 311-8. http://www.ncbi.nlm.nih.gov/pubmed/20798515
  48. Forti, E., Bulgheroni, A., Cetin, Y., Hartung, T., Jennings, P., Pfaller, W., and Prieto, P., Characterisation of cadmium chloride induced molecular and functional alterations in airway epithelial cells. Cell Physiol Biochem, 2010. 25(1): p. 159-68. http://www.ncbi.nlm.nih.gov/pubmed/20054154
  49. Lhotta, K., Gehringer, A., Jennings, P., Kronenberg, F., Brezinka, C., Andersone, I., and Strazdins, V., Familial juvenile hyperuricemic nephropathy: report on a new mutation and a pregnancy. Clin Nephrol, 2009. 71(1): p. 80-3. http://www.ncbi.nlm.nih.gov/pubmed/19203555
  50. Jennings, P., Aydin, S., Bennett, J., McBride, R., Weiland, C., Tuite, N., Gruber, L.N., Perco, P., Gaora, P.O., Ellinger-Ziegelbauer, H., Ahr, H.J., Kooten, C.V., Daha, M.R., Prieto, P., Ryan, M.P., Pfaller, W., and McMorrow, T., Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro, 2009. 23(3): p. 486-99. http://www.ncbi.nlm.nih.gov/pubmed/19159671
  51. Vinken, M., Doktorova, T., Ellinger-Ziegelbauer, H., Ahr, H.J., Lock, E., Carmichael, P., Roggen, E., van Delft, J., Kleinjans, J., Castell, J., Bort, R., Donato, T., Ryan, M., Corvi, R., Keun, H., Ebbels, T., Athersuch, T., Sansone, S.A., Rocca-Serra, P., Stierum, R., Jennings, P., Pfaller, W., Gmuender, H., Vanhaecke, T., and Rogiers, V., The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays. Mutat Res, 2008. 659(3): p. 202-10. http://www.ncbi.nlm.nih.gov/pubmed/18514569
  52. Wieser, M., Stadler, G., Jennings, P., Streubel, B., Pfaller, W., Ambros, P., Riedl, C., Katinger, H., Grillari, J., and Grillari-Voglauer, R., hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics. Am J Physiol Renal Physiol, 2008. 295(5): p. F1365-75. http://www.ncbi.nlm.nih.gov/pubmed/18715936
  53. Lechleitner, T., Klauser, F., Seppi, T., Lechner, J., Jennings, P., Perco, P., Mayer, B., Steinmuller-Nethl, D., Preiner, J., Hinterdorfer, P., Hermann, M., Bertel, E., Pfaller, K., and Pfaller, W., The surface properties of nanocrystalline diamond and nanoparticulate diamond powder and their suitability as cell growth support surfaces. Biomaterials, 2008. 29(32): p. 4275-84. http://www.ncbi.nlm.nih.gov/pubmed/18701160
  54. Lechner, J., Malloth, N., Seppi, T., Beer, B., Jennings, P., and Pfaller, W., IFN-alpha induces barrier destabilization and apoptosis in renal proximal tubular epithelium. Am J Physiol Cell Physiol, 2008. 294(1): p. C153-60. http://www.ncbi.nlm.nih.gov/pubmed/18032529
  55. Aydin, S., Signorelli, S., Lechleitner, T., Joannidis, M., Pleban, C., Perco, P., Pfaller, W., and Jennings, P., Influence of microvascular endothelial cells on transcriptional regulation of proximal tubular epithelial cells. Am J Physiol Cell Physiol, 2008. 294(2): p. C543-54. http://www.ncbi.nlm.nih.gov/pubmed/18057119
  56. Jennings, P., Koppelstaetter, C., Aydin, S., Abberger, T., Wolf, A.M., Mayer, G., and Pfaller, W., Cyclosporine A induces senescence in renal tubular epithelial cells. Am J Physiol Renal Physiol, 2007. 293(3): p. F831-8. http://www.ncbi.nlm.nih.gov/pubmed/17596534
  57. Bijuklic, K., Jennings, P., Kountchev, J., Hasslacher, J., Aydin, S., Sturn, D., Pfaller, W., Patsch, J.R., and Joannidis, M., Migration of leukocytes across an endothelium-epithelium bilayer as a model of renal interstitial inflammation. Am J Physiol Cell Physiol, 2007. 293(1): p. C486-92. http://www.ncbi.nlm.nih.gov/pubmed/17428840
  58. Jennings, P., Aydin, S., Kotanko, P., Lechner, J., Lhotta, K., Williams, S., Thakker, R.V., and Pfaller, W., Membrane targeting and secretion of mutant uromodulin in familial juvenile hyperuricemic nephropathy. J Am Soc Nephrol, 2007. 18(1): p. 264-73. http://www.ncbi.nlm.nih.gov/pubmed/17151335
  59. Lechner, J., Malloth, N.A., Jennings, P., Heckl, D., Pfaller, W., and Seppi, T., Opposing roles of EGF in IFN-alpha-induced epithelial barrier destabilization and tissue repair. Am J Physiol Cell Physiol, 2007. 293(6): p. C1843-50. http://www.ncbi.nlm.nih.gov/pubmed/17913840
  60. Hahn, H., Huck, C.W., Rainer, M., Najam-ul-Haq, M., Bakry, R., Abberger, T., Jennings, P., Pfaller, W., and Bonn, G.K., Analysis of glutathione in supernatants and lysates of a human proximal tubular cell line from perfusion culture upon intoxication with cadmium chloride by HPLC and LC-ESI-MS. Anal Bioanal Chem, 2007. 388(8): p. 1763-9. http://www.ncbi.nlm.nih.gov/pubmed/17594082
  61. Abberger, T., Jennings, P., Mirlach, A., Prajczer, S., and Pfaller, W., Application of a population balance model to a perfusion in vitro toxicity system. Toxicol In Vitro, 2006. 20(7): p. 1213-24. http://www.ncbi.nlm.nih.gov/pubmed/16713169
  62. Prieto, P., Baird, A.W., Blaauboer, B.J., Castell Ripoll, J.V., Corvi, R., Dekant, W., Dietl, P., Gennari, A., Gribaldo, L., Griffin, J.L., Hartung, T., Heindel, J.J., Hoet, P., Jennings, P., Marocchio, L., Noraberg, J., Pazos, P., Westmoreland, C., Wolf, A., Wright, J., and Pfaller, W., The assessment of repeated dose toxicity in vitro: a proposed approach. The report and recommendations of ECVAM workshop 56. Altern Lab Anim, 2006. 34(3): p. 315-41. http://www.ncbi.nlm.nih.gov/pubmed/16831063
  63. Wemhoner, A., Frick, M., Dietl, P., Jennings, P., and Haller, T., A fluorescent microplate assay for exocytosis in alveolar type II cells. J Biomol Screen, 2006. 11(3): p. 286-95. http://www.ncbi.nlm.nih.gov/pubmed/16699129
  64. Bijuklic, K., Sturn, D.H., Jennings, P., Kountchev, J., Pfaller, W., Wiedermann, C.J., Patsch, J.R., and Joannidis, M., Mechanisms of neutrophil transmigration across renal proximal tubular HK-2 cells. Cell Physiol Biochem, 2006. 17(5-6): p. 233-44. http://www.ncbi.nlm.nih.gov/pubmed/16790999
  65. Koppelstaetter, C., Jennings, P., Hochegger, K., Perco, P., Ischia, R., Karkoszka, H., and Mayer, G., Effect of tissue fixatives on telomere length determination by quantitative PCR. Mech Ageing Dev, 2005. 126(12): p. 1331-3. http://www.ncbi.nlm.nih.gov/pubmed/16182339
  66. Jennings, P., Bertocchi, C., Frick, M., Haller, T., Pfaller, W., and Dietl, P., Ca2+ induced surfactant secretion in alveolar type II cultures isolated from the H-2Kb-tsA58 transgenic mouse. Cell Physiol Biochem, 2005. 15(1-4): p. 159-66. http://www.ncbi.nlm.nih.gov/pubmed/15665525
  67. Frick, M., Bertocchi, C., Jennings, P., Haller, T., Mair, N., Singer, W., Pfaller, W., Ritsch-Marte, M., and Dietl, P., Ca2+ entry is essential for cell strain-induced lamellar body fusion in isolated rat type II pneumocytes. Am J Physiol Lung Cell Mol Physiol, 2004. 286(1): p. L210-20. http://www.ncbi.nlm.nih.gov/pubmed/14504067
  68. Koppelstaetter, C., Jennings, P., Ryan, M.P., Morin, J.P., Hartung, T., and Pfaller, W., Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 1: technical description. ALTEX, 2004. 21(2): p. 51-60. http://www.ncbi.nlm.nih.gov/pubmed/15195225
  69. Jennings, P., Koppelstaetter, C., Pfaller, W., Morin, J.P., Hartung, T., and Ryan, M.P., Assessment of a new cell culture perfusion apparatus for in vitro chronic toxicity testing. Part 2: toxicological evaluation. ALTEX, 2004. 21(2): p. 61-6. http://www.ncbi.nlm.nih.gov/pubmed/15195226
  70. Felder, E., Jennings, P., Seppi, T., and Pfaller, W., LLC-PK(1) cells maintained in a new perfusion cell culture system exhibit an improved oxidative metabolism. Cell Physiol Biochem, 2002. 12(2-3): p. 153-62. http://www.ncbi.nlm.nih.gov/pubmed/12077561

 

 

Book contributions

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  1. Jennings, P., In vitro-to-In Vivo Relationships with Respect to Kidney Safety Biomarkers. Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers2016: John Wiley & Sons, Incorporated. https://books.google.at/books?id=6ivdCQAAQBAJ
  2. Wilmes, A. and Jennings, P., The Use of Renal Cell Culture for Nephrotoxicity Investigations, in Predictive Toxicology: From vision to reality, volume 64. 2014, Wiley-VCH Verlag GmbH & Co. KGaA. p. 195-216. http://eu.wiley.com/WileyCDA/WileyTitle/productCd-3527336087.html
  3. Bal-Price, A. and Jennings, P., Preface, in In Vitro Toxicology Systems, Bal-Price, A. and Jennings P., Editors. 2014, Springer New York. p. ix-xii. http://www.springer.com/biomed/pharmacology+%26+toxicology/book/978-1-4939-0520-1
  4. Limonciel, A., The Past, Present, and Future of Chemical Risk Assessment, In Vitro Toxicology Systems 2014. p. 3-23. http://www.springerprotocols.com/Abstract/doi/10.1007/978-1-4939-0521-8_1
  5. Jennings, P., Aschauer, L., Wilmes, A., and Gstraunthaler, G., Renal Cell Culture, in In Vitro Toxicology Systems, Bal-Price, A. and Jennings P., Editors. 2014, Springer New York. p. 79-101. http://dx.doi.org/10.1007/978-1-4939-0521-8_4
  6. Leonard, M.O., Limonciel, A., and Jennings, P., Stress Response Pathways, in In Vitro Toxicology Systems, Bal-Price, A. and Jennings P., Editors. 2014, Springer New York. p. 433-458. http://dx.doi.org/10.1007/978-1-4939-0521-8_19
  7. Rauch, C., Jennings, P., and Wilmes, A., Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening, in In Vitro Toxicology Systems, Bal-Price, A. and Jennings P., Editors. 2014, Springer New York. p. 335-350. http://dx.doi.org/10.1007/978-1-4939-0521-8_15
  8. Wilmes, A., Limonciel, A., Leonard, M., and Jennings, P., Translational Biomarkers, In Vitro and In Vivo, in In Vitro Toxicology Systems, Bal-Price, A. and Jennings P., Editors. 2014, Springer New York. p. 459-478. http://dx.doi.org/10.1007/978-1-4939-0521-8_20
  9. Jennings, P., Epithelial Cell Cultures as tools to study human disease and the adverse effects of pharmaceuticals and chemicals. Habilitation Thesis, Innsbruck Medical University., 2009: p. 1-93.
  10. Jennings, P., Koppelstaetter, C., Lechner, J., and Pfaller, W., Renal culture models: Contribution to the understanding of nephrotoxic mechanisms. Clinical Nephrotoxins: Renal Injury from drugs and chemicals 2008. Third Edition: p. 223-250. http://link.springer.com/chapter/10.1007%2F978-0-387-84843-3_10
  11. Jennings, P., Koppelstätter, C., Lechner, J., and Pfaller, W., Renal cell culture models: Contribution to the understanding of nephrotoxic mechanisms, in Clinical Nephrotoxins2008, Springer US. p. 223-249.
  12. Jennings, P., Koppelstaetter, C., Helbert, M.J., and Pfaller, W., Renal culture models: Contribution to the understanding of nephrotoxic mechanisms. Clinical Nephrotoxins: Renal Injury from drugs and chemicals 2003. Second Edition: p. 115-147. http://link.springer.com/chapter/10.1007%2F1-4020-2586-6_7
  13. Jennings, P., Novel Approaches For In Vitro Nephrotoxicity Testing. PhD thesis, University College Dublin Library., 2001.

Paul Jennings