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home>molbio>CVs>CV-Loidl.html

Peter Loidl Ph.D.

peter_loidlE-Mail: peter.loidl[at]i-med.ac.at

 

 

 

Short curriculum

Date of birth: 1954-12-26, 
grown up in Grein/Donau and Bregenz

1979 Ph.D. (Biochemistry, Plant Physiology) after studies at the Faculty of Sience
and the Faculty of Medicine of the University of Innsbruck
1988  "Habilitation" (venia docendi) in Biochemistry 
June 1998  Professor of Microbiology 
1998-2001  Chairman of the Department of Microbiology (Medical School) of the
University of Innsbruck 
1999-2003  Vize-Rector for Evaluation of Research, Studies and Administration at
the University of Innsbruck 
since 2001  Professor of Microbiology at the Department of Molecular Biology 
2002-2003  Chairman of the Department of Molecular Biology of
the University of Innsbruck 
since 2005 Head of the Divsion of Molecular Biology, Innsbruck Biocenter,
Innsbruck Medical University 
since 2011 Course Director Molecular Medicine 
since 2013 Vice-Rector for Teaching and Study Affairs

 

Research fields

  • Chromatin structure and function
  • Histone modifying enzymes
  • Modifications of chromatin during the cell cycle
  • Acetylation of regulatory non-histone proteins

 

Awards

1984 Hoechst-Award
1985 Research-Award of Innsbruck (Forschungspreis d. Landeshauptstadt Innsbruck)
1987 Biochemie-Award
1993 Sandoz-Award
1995 Award of the Austrian Cancer Society
2006 Teacher-of-the-year award 2006 at Innsbruck Medical University

 

Teaching

  • Main lectures and practical courses in medical microbiology for students of medicine, lectures and lectures in molecular biology for biology students
  • Special lectures on the structure and function of chromatin, regulation of the cell cycle, structure and function of proteins, and regulation of gene expression
  • Advanced practical training in biochemistry (protein purification)
  • Supervision of master and Ph.D. theses, M.D. theses

 

Publications

  1. Loidl, P., Linortner, Ch. & Sachsenmaier, W. (1979) Timing of mitosis and DNA replication in mixed heterophasic plasmodia of Physarum polycephalum. In: Current Research on Physarum (Sachsenmaier, W., ed.), Veröffentlichungen der Universität Innsbruck, Vol. 120, 157-162.
  2. Loidl, P., Gröbner, P., Csordas, A. & Puschendorf, B. (1981) Effect of sodium-n-butyrate in Physarum polycephalum. In: Biology of Physarum (Rakoczy, L., ed.), Jagiellonian University Press, Cracow, Poland, p.90-97.
  3. Gröbner, P. & Loidl, P. (1981) Thymidylate synthesis in Physarum polycephalum. In: Biology of Physarum (Rakoczy, L., ed.), Jagiellonian Univ. Press, Cracow, Poland, p.181-190.
  4. Loidl, P. & Gröbner, P. (1981) Acceleration of nuclear division by extracts of Physarum polycephalum. In: Biology of Physarum (Rakoczy, L., ed.), Jagiellonian University Press, Cracow, Poland, p.84-89.
  5. Loidl, P., Fuchs, D., Gröbner, P., Hausen, A., Reibnegger, G. & Wachter, H. (1982) Pteridines during growth and differentiation of Physarum polycephalum. In: Biochemical and Clinical Aspects of Pteridines (Wachter, H., Curtius, H.Ch., Pfleiderer, W., eds.), Walter de Gruyter, Berlin-New York, p.257-266.
  6. Gröbner, P. & Loidl, P. (1982) Action of 5-Fluorodeoxyuridine on synchronous nuclear division and thymidylate synthetase activity in Physarum polycephalum. FEBS Lett. 140, 41.
  7. Loidl, P. & Gröbner, P. (1982) Acceleration of mitosis induced by mitotic stimulators of Physarum polycephalum. Exp. Cell Res. 137, 469.
  8. Loidl, P., Gröbner, P., Csordas, A. & Puschendorf, B. (1982) Cell cycle dependent effects of sodium-n-butyrate in Physarum polycephalum. J. Cell Sci. 58, 303.
  9. Gröbner, P. & Loidl, P. (1982) Thymidylate synthetase during synchronous nuclear division cycle and differentiation of Physarum polycephalum. Biochim. Biophys. Acta 697, 83.
  10. Loidl, P. & Sachsenmaier, W. (1982) Control of mitotic synchrony in Physarum polycephalum. Phase shifting by fusion of heterophasic plasmodia contradicts a limit cycle oscillator model. Eur. J. Cell Biol. 28, 175.
  11. Loidl, P., Fuchs, D., Gröbner, P., Hausen, A., Reibnegger, G., Wachter, H., Schweiger, M. & Gerisch, G. (1983) Pteridines in Dictyostelium discoideum and Physarum polycephalum. In: Chemistry and Biology of Pteridines (Blair, J.A., ed.), Walter de Gruyter, Berlin-New York, p.897-901.
  12. Gröbner, P & Loidl, P. (1983) Thymidylate synthetase during proliferation and differentiation of Physarum polycephalum. In: Chemistry and Biology of Pteridines (Blair, J.A., ed.), Walter de Gruyter, Berlin-New York, p.717-721.
  13. Gröbner, P. & Loidl, P. (1983) Response of the deoxythymidylate-synthesizing enzymes to differentiation processes in Physarum polycephalum. Exp. Cell Res. 144, 385.
  14. Loidl, P., Loidl, A., Puschendorf, B. & Gröbner, P. (1983) Lack of correlation between histone H4 acetylation and transcription during the Physarum cell cycle. Nature 305, 446.
  15. Gröbner, P.& Loidl, P. (1984) Thymidine kinase. A novel affinity chromatography of the enzyme and its regulation by phosphorylation in Physarum polycephalum. J. Biol. Chem. 259, 8012.
  16. Pfaller, W., Loidl, P., Gstraunthaler, G. & Gröbner, P. (1984) Auswirkung von alpha-Strahlen auf das Proliferationsverhalten von kultivierten Zellsystemen. Z. Phys. Med. Baln. Med. Klim. 13, 17-24.
  17. Djondjurov, L., Loidl, P., Yancheva, N., Sachsenmaier, W. & Tsanev, R. (1984) Metabolic behaviour of nonhistone chromosomal proteins during differentiation (spherulation) of Physarum polycephalum. Int. J. Biochem. 16, 1395.
  18. Loidl, P., Loidl, A., Puschendorf, B. & Gröbner, P. (1984) RNA polymerase activity and template activity of chromatin after butyrate induced hyperacetylation of histones in Physarum. Nucleic Acids Res. 12, 5405.
  19. Gröbner, P. & Loidl, P. (1985) ADP-ribosyltransferase in isolated nuclei during the cell cycle of Physarum polycephalum. Biochem. J. 232, 21.
  20. Gröbner, P. & Loidl, P. (1985) An immunological approach to enrich a mitotic stimulator and to reveal G2-phase specific proteins in Physarum polycephalum. J. Cell Biol. 100, 1930.
  21. Loidl, P. & Gröbner, P. (1986) Biosynthesis and posttranslational acetylation of histones during spherulation of Physarum polycephalum. Nucleic Acids Res. 14, 3745.
  22. Hardman, N., Bradbury, E.M., Braun, R., Christensen, M., Czupryn, M., Epstein, E., Foote, A., Kostelny, S., Loidl, P., Opstelten, J., Pearston, D., Vogt, V., Wanka, F., Waterborg, J. & Wilhelm, F.X. (1986) Molecular Organization of the Physarum genome. In: The Molecular Biology of Physarum polycephalum (Dove, W.E., Dee, J., Hatano, S., Haugli, F.B., Wohlfarth-Bottermann, K.E., eds.), NATO ASI Series, Life Sciences, vol.1, p.39-66, Plenum Press, New York-London.
  23. Laffler, T., Tyson, J., Barnes, L., Braun, R., Burland, T., Carrino, J., Cox, R., Daniel, J., Evans, H., Exenberger, R., Garcia-Herdugo, G., Green, L., Loidl, P., McNicol, A., Matthews, H., Mitchison, J., Paul, E., Sauer, H., Waterborg, J., Wilhelm, F. & Wright, M. (1986) The  Physarum Cell Cycle. In: The Molecular Biology of Physarum polycephalum ( Dove, W.E., Dee, J., Hatano, S., Haugli, F.B., Wohlfarth-Bottermann, K.E., eds.), NATO ASI Series, Life Sciences, vol.1, p.79-109, Plenum Press, New York-London.
  24. Loidl, P. & Gröbner, P. (1987) Histone synthesis during the cell cycle of Physarum polycephalum: Synthesis of different histone species is not under a common regulatory control. J. Biol. Chem. 262, 10195.
  25. Golderer, G., Loidl, P. & Gröbner, P. (1987) Histone-acetyltransferase activity during the cell cycle. FEBS Lett. 222, 322.
  26. Loidl, P. & Gröbner, P. (1987) Postsynthetic acetylation of core histones during the cell cycle: a general function for the displacement of histones during chromatin rearrangements. Nucleic Acids Res. 15, 8351.
  27. Loidl, P. (1988) Towards an understanding of the biological function of histone acetylation. FEBS Lett. 227, 91.
  28. Smolarz, E., Gröbner, P. and Loidl, P. (1988) Periodic fluctuations of nuclear high mobility group like proteins during the cell cycle of Physarum polycephalum. Biochemistry 27, 4142.
  29. Golderer, G., Schneider, R., Auer, B., Loidl, P. and Gröbner, P. (1988) ADP-ribosylation in isolated nuclei of Physarum polycephalum. Biochem. J. 253, 859-867.
  30. Waitz, W. and Loidl, P. (1988) In situ preparation of the nuclear matrix of Physarum polycephalum. Ultrastructural and biochemical analysis of different isolation procedures. J. Cell Sci. 90, 621-628.
  31. Pfaller, W., Gstraunthaler, G. and Loidl, P. (1990) Morphology of the differentiation and maturation of LLCPK1 epithelia. J. Cellular Physiol. 142, 247-254.
  32. Waitz, W. and Loidl, P. (1991) Cell cycle dependent association of c-myc protein with the nuclear matrix. Oncogene 6, 29-35.
  33. Golderer, G., Loidl, P. and Gröbner, P. (1991) ADP-ribosylation of the nuclear matrix. Eur. J. Cell Biol. 55, 183-186.
  34. Greil, R., Fasching, B., Loidl, P. and Huber, H. (1991) Expression of the c-myc protooncogene in multiple myeloma and chronic lymphocytic leukemia: an in situ analysis. Blood 78, 180-191.
  35. López-Rodas, G., Georgieva, E., Sendra, R. and Loidl, P. (1991) Histone acetylation in Zea mays I. Activities of histone acetyltransferases and histone deacetylases. J. Biol. Chem. 266, 18745-18750.
  36. Georgieva, E., López-Rodas, G., Sendra, R., Gröbner, P. and Loidl, P. (1991) Histone acetylation in Zea mays II. Biological significance of posttranslational histone acetylation during embryo germination. J. Biol. Chem. 266, 18751-18760.
  37. Golderer, G., Loidl, P. and Gröbner, P. (1992) ADP-Ribosylation of the nuclear matrix in Physarum polycephalum. Cell Biol. Int. Rep. 16, 1145-1150.
  38. Brosch, G., López-Rodas, G., Golderer, G., Lindner, H., Gröbner, P. and Loidl, P. (1992) Histone acetyltransferases and histone deacetylases of Physarum polycephalum. Cell Biol. Int. Rep. 16, 1103-1109.
  39. López-Rodas, G., Brosch, G., Golderer, G., Lindner, H., Gröbner, P. and Loidl, P. (1992) Enzymes involved in the dynamic equilibrium of core histone acetylation of Physarum polycephalum. FEBS Lett. 296, 82-86.
  40. López-Rodas, G., Lang, S., Loidl, A., Fasching, B., Greil, R. and Loidl, P. (1992) Nuclear proto-oncogene homologous proteins during the cell cycle of Physarum polycephalum. Cell Biol. Int. Rep. 16, 1185-1191.
  41. Greil, R., Fasching, B., Weger, A. and Loidl, P. (1992) Investigation of nuclear c-myc oncoprotein expression in human hematopoiesis: suitability of a rapid and reliable semiquantitative evaluation system based on computer-assisted image analysis. Lab.Invest. 66, 251-260.
  42. Grabher, A., Eberharter, A., Gstraunthaler, G. and Loidl, P. (1992) Characterization of nuclear matrix proteins of Physarum polycephalum and mammalian cells. Cell Biol. Int. Rep. 16, 1151-1157.
  43. Andreeva, M., Markova, D., Loidl, P. and Djondjurov, L. (1992) Intranuclear compartmentalization of transcribed and non-transcribed c-myc sequences in Namalva-S cells. Eur. J. Biochem. 207, 887-894.
  44. Loidl, P., Lucchini, R. and Sogo, J.M. (1992) Histone composition and core histone acetylation of transcriptionally active ribosomal chromatin of Physarum polycephalum. Cell Biol. Int. Rep. 16, 1177-1182.
  45. Brosch, G., Georgieva, E., López-Rodas, G., Lindner, H. and Loidl, P. (1992) Specificity of Zea mays Histone Deacetylase Is Regulated by Phosphorylation. J. Biol. Chem. 267, 20561-20564.
  46. Lang, S., Decristoforo, T. and Loidl, P. (1992) Synthesis and characterization of nuclear matrix proteins during the cell cycle of Physarum polycephalum. Cell Biol. Int. Rep. 16, 1169-1175.
  47. Greil, R., Weger, A., Fasching, B. and Loidl, P. (1992) Analysis of nuclear c-MYC oncoprotein expression: suitability of a semiquantitative evaluation system based on computer-assisted image analysis (CAS). Cell. Molec. Biol. 6, 63-69.
  48. Greil, R., Loidl, P., Fasching, B. and Huber, H. (1992) Differential expression of c-myc mRNA and c-MYC protein during terminal neoplastic B-cell differentiation. Curr. Topics Microbiol. Immunol. 182, 215-221.
  49. Eberharter, A., Grabher, A., Gstraunthaler, G. and Loidl, P. (1993) Biochemical and immunological characterization of the nuclear matrix: a comparison of the lower eucaryot Physarum polycephalum and a mammalian cell line. Eur. J. Biochem. 212, 573-580.
  50. López-Rodas, G., Brosch, G., Georgieva, E.I., Sendra, R., Franco, L. and Loidl, P. (1993) Histone deacetylase - a key enzyme for the binding of regulatory proteins to chromatin. FEBS Lett. 317, 175-180.
  51. Lang, S. and Loidl, P. (1993) Identification of proteins immunologically related to vertebrate lamins in the nuclear matrix of the myxomycete Physarum polycephalum. Eur. J. Cell Biol. 61, 177-183.
  52. Lang, S., Decristoforo, T., Waitz, W. and Loidl, P. (1993) Biochemical and morphological characterization of the nuclear matrix during the synchronous cell cycle of Physarum polycephalum. J. Cell Sci. 105, 1121-1130.
  53. Georgieva, E., López-Rodas, G., Hittmair, A., Feichtinger, H., Brosch, G. and Loidl, P. (1994) Maize embryo germination: I. Cell cycle analysis. Planta 192, 118-124.
  54. Georgieva, E., López-Rodas, G. and Loidl, P. (1994) Maize embryo germination: II. Proteins related to nuclear proto-oncogene- and tumor suppressor gene products. Planta 192, 125-129.
  55. Loidl, P. (1994) Histone acetylation: facts and questions. Chromosoma 103, 441-449.
  56. Grabher, A., Brosch, G., Sendra, R., Lechner, T., Eberharter, A., Georgieva, E.I., López- Rodas, G., Franco, L., Dietrich, H. and Loidl, P. (1994) Intracellular location of enzymes involved in core histone acetylation. Biochemistry 33, 14887-14895.
  57. Brosch, G., Ransom, R., Lechner, T., Walton, J. and Loidl, P. (1995) Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum. Plant Cell 7, 1941-1950.
  58. Loidl, P. and Eberharter, A. (1995) Nuclear matrix and the cell cycle. Int. Rev. Cytol. 162B, 377-403.
  59. Lechner, T., Lusser, A., Brosch, G., Eberharter, A., Goralik-Schramel, M. and Loidl, P. (1996) A comparative study of histone deacetylases of plant, fungal and vertebrate cells. Biochim. Biophys. Acta 1296, 181-188.
  60. Eberharter, A., Lechner, T., Goralik-Schramel, M. and Loidl, P. (1996) Purification and Characterization of the Cytoplasmic Histone Acetyltransferase B of Maize Embryos. FEBS Lett. 386, 75-81.
  61. Loidl, A. and Loidl, P. (1996) Proto-oncogenes and cell cycle regulators in plants and lower eukaryotes. Crit. Rev. Oncogenesis 7, 49-64.
  62. Brosch, G., Goralik-Schramel, M. and Loidl, P. (1996) Purification of Histone Deacetylase HD1-A of Germinating Maize Embryos. FEBS Lett. 393, 287-291.
  63. Brosch, G., Lusser, A., Goralik-Schramel, M. and Loidl, P. (1996) Purification and Characterization of a High Molecular Weight Histone Deacetylase Complex (HD2) of Maize Embryos. Biochemistry 35, 15907-15914.
  64. Lusser, A., Brosch, G., López-Rodas, G. and Loidl, P. (1997) Histone acetyltransferases during the cell cycle and differentiation of Physarum polycephalum. Eur. J. Cell Biol. 74, 102-110.
  65. Lusser, A., Brosch, G., Loidl, A., Haas, H. and Loidl, P. (1997) Identification of maize histone deacetylase HD2 as an acidic nucleolar phosphoprotein. Science 277, 88-91.
  66. Jung, M., Hoffmann, K., Brosch, G. and Loidl, P. (1997) Analogues of Trichostatin A and Trapoxin B as histone deacetylase inhibitors. Bioorg. Med. Chem. Lett. 7, 1655-1658.
  67. Sommer, A., Hilfenhaus, S., Menkel, A., Kremmer, E., Seiser, C., Loidl, P. and Lüscher, B. (1997) Cell growth inhibition by Mad/Max through recruitment of histone deacetylase activity. Curr. Biol. 7, 357-364.
  68. Kölle, D., Sarg, B., Lindner, H. and Loidl, P. (1998) Substrate- and sequential site-specificity of cytoplasmic histone acetyltransferases of maize and rat liver. FEBS Lett. 421, 109-114.
  69. Dangl, M., Lusser, A., Brosch, G., Loidl, A., Haas, H. and Loidl, P. (1998) Second Family of Histone Deacetylases. Science 280, 1167.
  70. Kölle, D., Brosch, G., Lechner, T., Lusser, A. and Loidl, P. (1998) Biochemical Methods for Analysis of Histone Deacetylases. Methods 15, 323-331.
  71. Hoffmann, K., Brosch, G., Loidl, P. and Jung, M. (1999) A Non-Isotopic Assay for Histone Deacetylase Activity. Nucl. Acids Res. 27, 2057-2058.
  72. Kölle, D., Brosch, G., Lechner, T., Pipal, A., Helliger, W., Taplick, T. and Loidl, P. (1999) Different types of maize histone deacetylases are distinguished by a highly complex substrate- and site-specificity. Biochemistry 38, 6769-6773.
  73. Lusser, A., Eberharter, A., Loidl, A., Goralik-Schramel, M., Horngacher, M., Haas, H. and Loidl, P. (1999) Analysis of the Histone Acetyltransferase B Complex of Maize Embryos. Nucl. Acids Res. 27, 4427-4435.
  74. Jung, M., Brosch, G., Kölle, D., Scherf, H., Gerhäuser, C. and Loidl, P. (1999) Amide analogues of Trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J. Med. Chem. 42, 4669-4679.
  75. Lechner, T., Lusser, A., Pipal, A., Brosch, G., Loidl, A., Goralik-Schramel, M., Sendra, R., Wegener, S., Walton, J. and Loidl, P. (2000) Rpd 3 type histone deacetylases in maize embryos. Biochemistry 39, 1683-1692.
  76. Graessle, S., Dangl, M., Haas, H., Mair, K., Trojer, P., Brandtner, E.-M., Walton, J., Loidl, P. and Brosch, G. (2000) Characterization of two putative histone deacetylase genes from Aspergillus nidulans. Biochim. Biophys. Acta 1492, 120-126.
  77. Hoffmann, K., Brosch, G., Loidl, P. and Jung, M. (2000) First non-radioactive assay for in vitro screening of histone deacetylase inhibitors. Pharmazie 55, 601-606.
  78. Dangl, M., Brosch, G., Haas, H., Loidl, P. and Lusser, A. (2001) Comparative analysis of HD2 type histone deacetylases in higher plants. Planta 213, 280-285.
  79. Lusser, A., Kölle, D. and Loidl, P. (2001) Histone acetylation: Lessons from the plant kingdom. Trends Plant Sci. 6, 59-65.
  80. Loidl, P. (2001) Assembly, remodeling and modification of chromatin. Cell. Mol. Life Sci. 58, 663-664.
  81. Graessle, S., Loidl, P. and Brosch, G. (2001) Histone acetylation: plants and fungi as modelb systems for the investigation of histone deacetylases. Cell. Mol. Life Sci. 58, 704-720.
  82. Massa, S., Mai, A., Sbardella, G., Esposito, M., Ragno, R., Loidl, P. and Brosch, G. (2001) 3- (4-Aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors. J. Med. Chem. 44, 2069-2072.
  83. Brosch, G., Baidyaroy, D., Ahn, J., Graessle, S., Wegener, S., Tonukari, N.J., Caballero, O., Loidl, P. and Walton, J.D. (2001). A gene related to yeast HOS2 histone deacetylase affects extracellular depolymerase expression and virulence in a plant pathogenic fungus. Plant Cell 13, 1609-1624.
  84. Wagner, M., Brosch, G., Zwerschke, W., Seto, E., Loidl, P. and Jansen-Dürr, P., (2001). Histone deacetylases in replicative senescence: Evidence for a senescence-specific form of HDAC-2. FEBS Lett. 499,101-106.
  85. Brosch, G., Dangl, M., Graessle, S., Loidl, A., Trojer, P., Brandtner, E.M., Mair, K., Walton, J.D., Baidyaroy, D. and Loidl, P. (2001). An inhibitor-resistant histone deacetylase in the plant pathogenic fungus Cochliobolus carbonum. Biochemistry 40, 12845-12863.
  86. Mai, A., Massa, S., Ragno, R., Esposito, M., Sbardella, G., Nocca, G., Scatena, R., Jesacher, F., Loidl, P. and Brosch, G. (2002). Binding Mode Analysis of 3-(4-Benzoyl-1- methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: A New Synthetic Histone Deacetylase Inhibitor Inducing Histone Hyperacetylation, Growth Inhibition, and Terminal Cell Differentiation. J. Med. Chem. 45, 1778-1784.
  87. Wittich, S., Scherf, H., Xie, C., Brosch, G., Loidl, P., Gerhäuser, C. and Jung, M. (2002). Structure-activity relationships on phenylalanine containing inhibitors of histone deacetylase - In-vitro enzyme inhibition, induction of differentiation and inhibition of proliferation in Friend leukemic cells. J. Med. Chem. 45, 3296-3309.
  88. Brandtner, E.M., Lechner, T., Loidl, P. and Lusser, A. (2002). Molecular identification of PpHDAC1, the first histone deacetylase from the slime mold physarum polycephalum. Cell Biol. Int. 26, 783-789.
  89. Mai, A., Massa, S., Ragno, R., Cerbara, I., Jesacher, F., Loidl, P. and Brosch, G. (2003). 3- (4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 1. Design, Synthesis, Biological Evaluation, and Bindin Mode Studies Performed Through Three Different Docking Procedures. J. Med. Chem. 46, 512-24.
  90. Trojer, P., Brandtner, E.M., Brosch, G., Loidl, P., Galehr, J., Linzmaier, R., Haas, H., Mair, K., Tribus, M. and Graessle, S. (2003). Histone deacetylases in fungi: novel members, new facts. Nucl. Acids Res. 31, 3971-3981.
  91. Pipal, A., Goralik-Schramel, M., Lusser, A., Lanzanova, C., Sarg, B., Loidl, A., Lindner, H., Rossi, V. and Loidl, P. (2003). Regulation and Processing of Maize Histone Deacetylase HDA1 by Limited Proteolysis. Plant Cell 15, 1904-1917.
  92. Mai, A., Massa, S., Pezzi, R., Rotili, D., Loidl, P. and Brosch, G. (2003). Discovery of (aryloxopropenyl)pyrrolyl-hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A. J. Med. Chem. 46, 4826-4829.
  93. Mai, A., Massa, S., Cerbara, I., Valente, S., Ragno, R., Bottoni, P., Scatena, R., Loidl, P. and Brosch, G. (2004). 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity. J. Med. Chem. 47, 1098-1109.
  94. Loidl, P. (2004). A plant dialect of the histone language. Trends Plant Sci. 9, 84-90.
  95. Ragno, R., Mai, A., Massa, S., Cerbara, I., Valente, S., Bottoni, P., Scatena, R., Jesacher, F., Loidl, P. and Brosch, G. (2004). 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2- propenamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 3. Discovery of Novel Lead Compounds Through Structure-Based Drug Design and Docking Studies. J. Med. Chem. 47, 1351-1359.
  96. Hildmann, C., Ninkovic, M., Dietrich, R., Wegener, D., Riester, D., Zimmermann, T., Birch, O. M., Bernegger, C., Loidl, P. and Schwienhorst, A. (2004) A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases. J. Bacteriol. 186, 2328-2339.
  97. Trojer, P., Dangl, M., Bauer, I., Graessle, S., Loidl, P. & Brosch, G. (2004). Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity. Biochemistry 43, 10834-10843.
  98. Mai, A., Massa, S., Pezzi, R., Simeoni, S., Rotili, D., Nebbioso, A., Scognamiglio, A., Altucci, L., Loidl, P., & Brosch, G. (2005). Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. J. Med. Chem. 48, 3344-3353.
  99. Rottmann, S., Menkel, A.R., Bouchard, C., Mertsching, J., Loidl, P., Kremmer, E., Eilers, M., Lüscher-Firzlaff, J., Lilischkis, R., & Lüscher, B. (2005). Mad1 Function in Cell Proliferation and Transcriptional Repression is Antagonized by Cyclin E/CDK2. J. Biol. Chem., 280,
    15489-15492.
  100. Tribus, M., Galehr, J., Trojer, P., Brosch, G., Loidl, P., Marx, F., Haas, H., & Graessle, S. (2005). HdaA, a Major Class 2 Histone Deacetylase of Aspergillus nidulans Affects Growth Under Conditions of Oxidative Stress. Eukaryot. Cell 4, 1736-1745.
  101. Mai, A., Massa, S., Pezzi, R., Valente, S., Loidl, P. & Brosch, G. (2005). Synthesis and Biological Evaluation of 2-, 3-, and 4-Acylaminocinnamyl-N-hydroxyamides as Novel Synthetic HDAC Inhibitors. Med. Chem. 1, 245-254.
  102. Meraner, J., Lechner, M., Loidl, A., Goralik-Schramel, M., Voit, R., Grummt, I. & Loidl, P. (2006). Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I. Nucl. Acids Res. 34, 1798-1806.
  103. Brosch, G., Loidl, P. & Graessle, S. (2008). Histone Modifications and Chromatin Dynamics: A Focus on Filamentous Fungi. FEMS Microbiol. Rev. 32, 409-439.
  104. Meraner, J., Lechner, M., Schwarze, F., Gander, R., Jesacher, F. & Loidl, P. (2008). Cell  cycle dependent role of HDAC1 for proliferation control through modulating ribosomal DNA transcription. Cell Biol. Int. 32, 1073-1080.
  105. Tribus, M., Bauer, I., Galehr, J., Rieser, G., Brosch, G., Loidl, P., Trojer, P., Haas, H. and Graessle, S. (2010). A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus. Molecular Biology of the Cell 21, 345-353.
  106. Bauer, I., Graessle, S., Loidl, P., Hohenstein, K., Brosch, G. (2010). Novel insights into the functional role of three protein arginine methyltransferases in Aspergillus nidulans. Fungal Genetics Biology 47(6):551-61.
  107. Schwarze, F., Meraner, J., Lechner, M., Loidl, A., Stasyk, T., Laich, A. & Loidl, P. (2010). Cell cycle dependent acetylation of Rb2/p130 in NIH3T3 cells. Oncogene 29, 5755-5760.
  108. Saeed, S., Schwarze, F., Loidl, A., Meraner, J., Lechner, M. and Loidl, P. (2012). In vitro phosphorylation and acetylation of the murine pocket protein Rb2/p130. PLoS ONE 7(9): e46174. doi:10.1371/journal.pone.0046174
  109. Ullah, F., Khurshid, N., Fatimi, Q., Loidl, P. and Saeed, M. (2022). Mutations in the acetylation hotspots of Rbl2 are associated with increased risk of breast cancer. PLoS ONE 17(4): e0266196. https://doi.org/10.1371/journal.pone.0266196

 

Private

Since 1979 married to Adele Loidl Ph.D., son Patrick (born 1980) and daughter Nora (born 1983).

Hobbies: music, piano playing, literature, fine arts, mountain biking, travelling, cooking, gardening.

Institut für Molekularbiologie