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Bernhard Redl Ph.D., Associate Professor

bernhard redl

EMail: bernhard.redl[at]i-med.ac.at

 

 

Short curriculum

1982

Ph.D. in Microbiology and Biochemistry

1993

"Habilitation" (venia docendi) in Microbiology

1995 

Assoc. Professor

2001-2002

Head of the Department of Molecular Biology

since 2003

Associate Professor (Venia docendi for Molecular Biology), Division of Molecular Biology,
Biocenter, Innsbruck Medical University

 

Research fields

Lipocalin Laboratory

 

Publications 

  1. Redl B. and Tiefenbrunner F. (1981) Determination of hydrolytic activities in waste water systems by microcalorimetry. Water Res. 15, 87-90.  

  2. Redl B. and Tiefenbrunner F. (1982) Microcalorimetric measurements of microbial metabolic activity in sewage digesting systems. Appl.Microbiol.Biotechnol. 12, 234-238.  

  3. Redl B. and Tiefenbrunner F.(1983) Microcalorimetric investigations on the action of certain metal ions to nongrowing E.coli cells. Thermochim.Acta 49, 111-122. 

  4. Redl B. and Tiefenbrunner F. (1984) The use of isothermal ampoule microcalorimeters for analytical investigations in waste water systems. Forum Städte-Hygiene 36, 319-326.  

  5. Redl B., Hofbauer C. and Stöffler G. (1984) Identification of protein-protein cross-links within the E.coli ribosome by immunoblotting techniques. Hoppe-Seylers Zeitschr.Physiol. Chemie, 365, 941-949. 

  6. Redl B. and Tiefenbrunner F. (1985) Practical and theoretical considerations for using isothermal microcalorimetry for monitoring microbial activities in ecological studies. Forum Städte-Hygiene 37, 312-319.  

  7. Tiefenbrunner F., Haller T., Weiß Ch. and Redl B. (1986) Methods for detection of microbial activities in solid waste samples. Microbiol.Res. 38, 144-150.  

  8. Stöffler G., Redl B., Walleczek J. and Stöffler-Meilicke M. (1987) Identification of protein-protein crosslinks within the E.coli ribosome by immunoblotting techniques. Meth.Enzymol. 164, 64-76.  

  9. Knosp O., Redl B. and Puschendorf B. (1988) Biochemical characterization of chromatin fractions isolated from induced and uninduced Friend Erythroleukemia cells. Mol.Cell.Biochem. 89, 37-46.  

  10. Redl B., Baier G. and Stöffler G. (1988) Purification and properties of the human tear protein PMFA. Biol.Chem. 369, 926-928.  

  11. Stöffler-Meilicke M., Walleczek J., Hackl W., Schuler D., Brimacombe R., Redl B. and Stöffler G. (1988) Topography of the ribosomal-proteins within the 50S subunit of E.coli. Biol.Chem. 369, 907-913. 

  12. Walleczek J., Redl B., Stöffler-Meilicke M. and Stöffler G. (1989) Protein-protein crosslinking of the 50S ribosomal subunit of E.coli using 2-iminothiolane. J.Biol.Chem. 264, 4231-4237.  

  13. Redl B., Walleczek J., Stöffler-Meilicke M. and Stöffler G. (1989) Immunoblotting analysis of protein-protein crosslinks within the 50S subunit of E.coli: a study using DMS as crosslinking reagent. Eur.J.Biochem. 181, 351-356.  

  14. Walleczek J., Martin Th., Redl B., Stöffler-Meilicke M. and Stöffler G. (1989) Comparative crosslinking study on the 50 S ribosomal subunit from E.coli. Biochemistry 28, 4099-4105.  

  15. Baier G., Wollensack G., Redl B., Stöffler G. and Göttinger W. (1990) Analysis of human tear proteins by different HPLC techniques. J.Chromatogr. 525, 319-328.  

  16. Hanner M., Redl B. and Stöffler G. (1990) Isolation and characterization of an intracellular aminopeptidase from the extreme thermophilic archaebacterium Sulfolobus solfataricus. Biochim.Biophys.Acta 1033, 148-153.  

  17. Puchegger S., Redl B. and Stöffler G. (1990) Purification and properties of fumarate hydratase from the extreme thermophilic archaeobacterium Sulfolobus solfataricus. J.Gen.Microbiol. 136, 1537-1541.  

  18. Baier G., Piendl W., Redl B. and Stöffler G. (1990) Structure, organization and evolution of the L1 equivalent ribosomal protein gene of the archaebacterium Methanococcus vannielii. Nucleic Acid Res. 18, 719-724.  

  19. Schinkinger M.F., Redl B. and Stöffler G. (1991) Purification and properties of an extreme thermostable glutamate dehydrogenase from the archaebacterium Sulfolobus solfataricus. Biochim.Biophys.Acta 1073, 142-148.  

  20. Haas H., Redl B., Leitner E. and Stöffler G. (1991) Penicillium chrysogenum extracellular acid phosphatase: purification and biochemical characterization. Biochim.Biophys.Acta 1074, 392-397.  

  21. Haas H., Redl B., Friendlin E. and Stöffler G. (1992) Isolation and analysis of the Penicillium chrysogenum phoA gene encoding a phosphate-repressible acid phosphatase. Gene 113, 129-134.  

  22. Fellinger W., Redl B. and Stöffler G. (1992) Sequence of the complete osp operon encoding two major outer membrane proteins of an European Borrelia burgdorferi isolate (B29). Gene 120, 127-128.  

  23. Haas H., Herfurth E., Stöffler G. and Redl B. (1992) Purification, characterization and partial amino acid sequences of a xylanase produced by Penicillium chrysogenum. Biochim.Biophys Acta 1117, 279-286.  

  24. Redl B., Holzfeind P. and Lottspeich F. (1992) cDNA cloning and sequencing reveals human tear prealbumin to be a member of the lipophilic-ligand carrier protein superfamily. J.Biol.Chem. 267, 20282-20287.  

  25. Haas H., Friedlin E., Stöffler G. and Redl B. (1993) Cloning and structural organization of a xylanase encoding gene from Penicillium chrysogenum. Gene 126, 237-242.  

  26. Reindl M., Stöffler G. and Redl B. (1993) Isolation and analysis of a linear plasmid located gene of Borrelia burgdorferi B29 encoding a 27 kDa surface lipoprotein (P27) and its over- expression in E.coli. Mol.Microbiol. 8, 1115-1124.  

  27. Fellinger W., Reindl M., Stöffler G. and Redl B. (1994) Multiple amino acid sequence alignment of the major outer surface proteins OspA and OspB of various Borrelia burgdorferi strains. in: Lyme Borreliosis (Axford J.S. and Rees D.H.E., eds), pp. 181-186 Plenum Press, N.Y.  

  28. Baumgartner M., Holzfeind P. and Redl B. (1994) Chromosomal assignment of the gene for human tear prealbumin (LCN1), a member of the lipocalin superfamily. Cytogenet.Cell Genet. 65, 101-104.  

  29. Reindl M., Redl B. and Stöffler G. (1994) A physical and genetic map of the 62-kb linear plasmid (lp-62) of Borrelia garinii strain B29. in: Advances in Lyme Borreliosis (eds. Cevenini R., Sambri V. and La Sambri V. and La Placa M.) p57-61.  

  30. Holzfeind P. and Redl B. (1994) Structural organization of the gene encoding the human lipocalin tear prealbumin (LCN1) and synthesis of the recombinant protein in E. coli. Gene 139, 177-183.  

  31. Fellinger W., Farencena A., Redl B., Sambri V., Cevenini, R. and Stöffler G. (1995) Amino acid sequence heterogeneity of the chromosomal encoded Borrelia burgdorferi major antigen P100. Microbiol. 18, 163-168.  

  32. Haas H., Bauer B., Redl B., Stöffler G. and Marzluf G.A. (1995) Molecular cloning and analysis of nre, the major nitrogen regulatory gene of Penicillium chrysogenum. Curr.Genet. 27, 150-158.  

  33. Herzog H., Baumgartner M., Holzfeind P. and Redl B. (1995) Confirmation of 9q34 as the chromosomal localization site of the human LCN1 gene. Cytogenet.Cell Genet. 69, 108-109.  

  34. Marx F., Haas H., Hofer S., Stöffler G. and Redl B. (1995) Sequence and structure of Penicillium chrysogenum phoG, homologous to an acid phosphatase encoding gene of Aspergillus nidulans. Gene 160, 137-139.  

  35. Holzfeind P., Merschak P., Dieplinger H. and Redl B. (1995) The human lacrimal gland synthesizes apolipoprotein D mRNA in addition to tear prealbumin mRNA, both species encoding members of the lipocalin superfamily. Exp.Eye Res. 61, 495-500.  

  36. Marx F., Haas H., Reindl M., Stöffler G., Lottspeich F. and Redl B. (1996) Cloning, structural organization and regulation of expression of the Penicillium chrysogenum paf gene encoding an abundantly secreted protein with antifungal activity. Gene 167, 167-171.  

  37. Holzfeind P., Merschak P., Rogatsch H., Feichtinger J., Klocker H. and Redl B. (1996) Expression of the gene for Tear Lipocalin/von Ebner´s gland protein in human prostate. FEBS Lett. 395, 95-99.  

  38. Grässle S., Haas H., Friedlin H., Kürnsteiner H., Stöffler G. and Redl B. (1997) Regulated system for heterologous gene expression in Penicillium chrysogenum. Appl.Environ.Microbiol. 63, 753-756.  

  39. Berger M., See D.M., Redl B., Aymard M. and Lina B. (1997) Direct in situ RT- PCR for the detection of Enterovirus genome in liver tissues. J.Virol. Methods 65, 55-66.  

  40. Holzfeind P., Merschak P., Wojnar P. and Redl B. (1997) Structure and organization of the porcine LCN1 gene encoding Tear lipocalin/ von Ebner´s gland protein. Gene 202, 61-67.  

  41. Berger M., See D., Redl B., Aymand M. and Lina B. (1997) Comparison of procedures for the detection of enteroviruses in murine heart by direct in situ PCR. Res.Virol. 148, 409-416.  

  42. Redl B., Wojnar P., Ellemunter H. and Feichtinger H. (1998) Identification of a lipocalin in mucosal glands of the human tracheobronchial tree and its enhanced secretion in cystic fibrosis. Lab.Invest. 78, 1121-1129.  

  43. Trojer P., Wojnar P., Merschak P. and Redl B.(1999) Complement component C8-gamma is expressed in human fetal and adult kidney independent of C8-alpha. FEBS Lett. 446, 243-246.  

  44. Redl B., Merschak P., Abt B. and Wojnar P. (1999) Phage display reveals a novel interaction of human lipocalin LCN1 and thioredoxin which is relevant for ligand binding. FEBS Lett. 460, 182-186.  

  45. Cepica S., Schröffel J., Redl B. and Rohrer, A.G. (1999) Linkage mapping of two TaqI PCR-RFLPs within intron 6 of the porcine gene (LCN1) encoding Tear lipocalin/von Ebner´s gland protein. Anim.Genet. 30, 467-468.  

  46. Cepica S., Yerle M., Stratil A., Schröffel J. and Redl B. (1999) Regional localization of porcine MYOD1, MYF5, LEP, UCP3 and LCN1 genes. Anim.Genet. 30, 476-478.  

  47. Berger M., Kopp N., Vital C., Redl B., Aymard M., Lina B. (2000) Detection and cellular localization of Enterovirus RNA sequences in spinal cord of patients with Amyotrophic Lateral Sclerosis (ALS). Neurology, 54, 20-25.  

  48. Redl B. (2000) Human Tear Lipocalin. Biochim. Biophys. Acta, 1482, 241-248. 

  49. Lechner M., Wojnar P. and Redl B. (2001) Human tear lipocalin acts as an oxidative-stress-induced scavenger of potentially harmful lipid peroxidation products in a cell culture system. Biochem J., 356, 129-135.  

  50. Wojnar P., Lechner M., Merschak P. and Redl B. (2001) Molecular cloning of a novel Lipocalin-1 interacting human cell membrane receptor (LIMR) using phage-display. J. Biol. Chem., 276(23), 20206-20212.  

  51. Wojnar P., van't Hof W., Merschak P., Lechner M. and Redl B. (2001) The N-terminal part of recombinant human Tear Lipocalin/von Ebner's gland protein confers cysteine proteinase inhibition depending on the presence of the entire cystatin-like motifs. Biol. Chem., 382(10), 1515-1520.  

  52. Wojnar P., Dirnhofer S., Ladurner P., Berger P. and Redl B. (2002) Human Lipocalin-1, a potential physiological scavenger of lipophilic compounds, is produced by corticotrophs of the pituitary gland. J. Histochem. Cytochem., 50(3), 433-435.  

  53. Wojnar P., Lechner M. and Redl B. (2003) Antisense downregulation of the lipocalin-interacting-membrane-receptor expression inhibits cellular internalization of Lipocalin-1 in human NT2 cells. J. Biol. Chem, 278, 16209-16215.  

  54. Fluckinger M., Haas H., Merschak P., Glasgow BJ. and Redl B. (2004) Human Tear Lipocalin exhibits antimicrobial activity by scavenging of microbial siderophores. Antimicrob. Agents Chemoth.48, 3367-3372  

  55. Breustedt D.A., Korndoerfer I.P., Redl B. and Skerra A. (2005) The 1.8 A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands. J. Biol. Chem. 280, 484-493.  

  56. Margesin R., Fonteyne P-A. and Redl B. (2005) Low-temperature biodegradation of high amounts of phenol by Rhodococcus spp. and basidiomycetous yeasts. Res. Microbiol. 156, 68-75.  

  57. Saaren-Sepp H., Jauhiainen M., Tervo T., Redl B., Kinnunen P. and Holopainen J. (2005). Interaction of purified Tear Lipocalin with lipid membranes. Invest. Ophth.Vis. Sci., 46, 3649-3656. 

  58. Burke B.J., Redondo C., Redl B. and Findlay J.B.C. (2006). Lipocalin Receptors: Into the Spotlight. In: Lipocalins, ed. Akerstroem B., Borregaard N., Flower, D.R. and Salier J-P., Landes Bioscience, USA ,pp. 157-166. 

  59. Gasymov O.K., Abduragimov A.R., Merschak P., Redl B. and Glasgow B.J. (2007) Oligomeric State of Lipocalin-1 (LCN-1) by Multiangle Laser Light Scattering and Fluorescence Anisotropy Decay. BBA-Proteins and Proteomics 1774, 1307-1315. 

  60. Teufel L., Schuster C.K. , Merschak, P., Bechtold T. and Redl B. (2008) Development of a fast and reliable method for the assessment of microbial colonization and growth on textiles by DNA quantification. J. Mol. Microbiol. Biotechnol. 14, 193-200.  

  61. Fluckinger M., Merschak P., Hermann M., Haertle T. and Redl B. (2008) Lipocalin-interacting-membrane-receptor (LIMR) mediates cellular internalization of beta-lactoglobulin. BBA-Biomembranes 1787, 342-347. 

  62. Wollensak G. and Redl B. (2008) Gel electrophoretic analysis of corneal collagen after photodynamic cross-linking treatment. Cornea 27, 353-356. 

  63. Teufel L., Pipal A., Schuster KC., Staudinger T. and Redl B. (2010) Material-dependent growth of human skin bacteria on textiles investigated by challenge tests and DNA-genotyping. J.Appl.Microbiol. 108, 450-461. 

  64. Sonnleitner R., Redl B., Merschak P. and Schinner F. (2011) Mobilization of metals from pristine mineral soil by nitrifying and sulfur-oxidizing bacteria - the leaching potential of indigenous culture enrichments. Geomicrobiol. J. 28, 212 - 220. 

  65. Staudinger T., Pipal A. and Redl B. (2011) Molecular analysis of the microbiota of human male and female forehead skin compared to forearm skin and the influence of make-up. J.Appl.Microbiol. 110, 1381-1389. 

  66. Sonnleitner R., Redl B. and Schinner F. (2011) Microbial mobilization of major and trace elements from catchment rock samples of a high mountain lake in the European alps. Arctic, Antarctic, and Alpine Res, 43, 465-474. 

  67. Sonnleitner, R.; Redl, B.; Pipal, A. Schinner, F. (2011) Chemolithotrophic Metal Mobilization from Dolomite. Geomicrobiology Journal. 28(8); 651-659. 

  68. Emam H.E., Manian A.P, Siroka B., Duelli H., Redl B., Pipal A. and Bechtold T. (2013) Treatments to impart antimicrobial activity to clothing and household cellulosic textiles - why nano silver? J. Cleaner Production, 39, 17-23. 

  69. Leal SM., Roy S., Vareechon C., Clark H., Carrion S., Lopes-Berges MS., di Pietro A., Schrettl M., Beckman N., Redl B., Haas H. and Pearlman E. (2013) Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum. PLOS Pathogens, 9(7):e1003436. 

  70. Staudinger T., Redl B. and Glasgow BJ. (2014) Antibacterial activity of rifamycins for M.smegmatis with comparison of oxidation and binding to tear lipocalin. BBA-Proteins and Proteomics 1844, 750-758. 

  71. Emam H.E., Manian A.P., Široká B., Duelli H., Merschak P., Redl B. and Bechtold T. (2014) Copper(I)oxide surface modified cellulose fibres - synthesis, characterisation and antimicrobial properties. Surf. Coat. Tech., 254, 344-351. 

  72. Turalija M., Merschak P., Redl B., Griesser U., Duelli H. and Bechtold T (2015) Copper(I)oxide microparticles - Synthesis and antimicrobial finishing of textiles. J.Mater.Chem.B. 3, 5886-5892. 

  73. Posch B., Irsara C., Gamper F., Herrmann M., Bindreither D., Fuchs D., Reider N., Redl B., Heufler C. (2015) Allergenic Can f 1 and its human homologue Lcn-1 direct dendritic cells to induce divergent immune responses. J.Cell.Mol.Med, 19, 2375-2384.

  74. Yang, Y., Bechtold T., Redl B., Caven B. and Hu H. (2017) A novel silver-containing absorbent wound dressing based on spacer fabric. J.Mater.Chem.B, 5, 6786-6793

  75. Waldner A., Dassati S., Redl B., Smania N and Gandolfi, M. (2018) Apolipoprotein D Concentration in Human Plasma during Aging and in Parkinson’s Disease: A cross-sectional study. Parkinson´s Disease, Vol. 2018, Article ID 3751516, 7 pages

  76. Caven B., Redl B., Bechtold T. (2019) Investigation into the possible antibacterial properties of wool fibers. Textile Res. J. 89(4), 510-516

  77. Habeler M., Lindner H.H., Redl B. (2020) A role of heparan sulphate proteoglycan in the cellular uptake of lipocalins ß-lactoglobulin and allergen Fel d 4. Biol Chem. 401(9), 1081-1092.

  78. Habeler M., Redl B. (2021) Phage-display reveals interaction of lipocalin allergen Can f 1 with a peptide resembling the antigen binding region of a human γδT-cell receptor. Biol Chem. 402(4), 433-437.

  79. Redl B. and Habeler M. (2022). The diversity of lipocalin receptors. Biochimie 192, 22-29.

Institut für Molekularbiologie