Publications
2023
Pietsch E., Ramaprasad A., Bielfeld S., Wohlfarter Y., Maco B., Niedermüller K., Wilcke L., Kloehn J., Keller M.A., Soldati-Favre D., Blackman M.J., Gilberger T.-W., Burda P.-C. A patatin-like phospholipase is important for mitochondrial function in malaria parasites. mBio (2023) 26;14(6):e0171823. Online ahead of print. http://dx.doi.org/10.1128/mbio.01718-23
Lackner K., Sailer S., van Klinken J.B., Wever E., Pras-Raves M.L., Dane A.D., Honsho M., Abe Y., Keller M.A., Golderer G., Werner-Felmayer G., Fujiki Y., Vaz F.M., Werner E.R., Watschinger K. Alterations in ether lipid metabolism and the consequences for the mouse lipidome. Biochim Biophys Acta Mol Cell Biol Lipids. (2023) 1868(4):159285. http://dx.doi.org/10.1016/j.bbalip.2023.159285
Werner E.R., Swinkels D., Juric V., Dorninger F., Baes M., Keller M.A., Berger J., Watschinger K.. Normal plasmalogen levels are maintained in tissues from mice with hepatocyte-specific deletion in peroxin 5. Brain Res Bull. (2023) Feb;193:158-165. http://dx.doi.org/10.1016/j.brainresbull.2022.12.007
Locher M., Jukic E., Vogi V., Keller M.A., Kröll T., Schwendinger S., Oberhuber K., Verdorfer I., Mühlegger B.E., Witsch-Baumgartner M., Nachbaur D., Willenbacher W., Gunsilius E., Wolf D., Zschocke J., Steiner N. Amp(1q) and tetraploidy are commonly acquired chromosomal abnormalities in relapsed multiple myeloma. Eur J Haematol. (2023) 110(3):296-304. http://dx.doi.org/10.1111/ejh.13905
2022
Wohlfarter Y., Eidelpes R., Yu R.D., Sailer S., Koch J., Karall D., Scholl-Bürgi S., Amberger A., Hillen H.S., Zschocke J., Keller M.A. Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism. Cell Mol Life Sci. (2022) Oct 22;79(11):562. http://dx.doi.org/10.1007/s00018-022-04579-6
Demichev V., Tober-Lau P., Nazarenko T., Lemke O., Kaur Aulakh S., Whitwell H.J., Röhl A., Freiwald A., Mittermaier M., Szyrwiel L., Ludwig D., Correia-Melo C., Lippert L.J., Helbig E.T., Stubbemann P., Olk N., Thibeault C., Grüning N.M., Blyuss O., Vernardis S., White M., Messner C.B., Joannidis M., Sonnweber T., Klein S.J., Pizzini A., Wohlfarter Y., Sahanic S., Hilbe R., Schaefer B., Wagner S., Machleidt F., Garcia C., Ruwwe-Glösenkamp C., Lingscheid T., Bosquillon de Jarcy L., Stegemann M.S., Pfeiffer M., Jürgens L., Denker S., Zickler D., Spies C., Edel A., Müller N.B., Enghard P., Zelezniak A., Bellmann-Weiler R., Weiss G., Campbell A., Hayward C., Porteous D.J., Marioni R.E., Uhrig A., Zoller H., Löffler-Ragg J., Keller M.A., Tancevski I., Timms J.F., Zaikin A., Hippenstiel S., Ramharter M., Müller-Redetzky H., Witzenrath M., Suttorp N., Lilley K., Mülleder M., Sander L.E.; PA-COVID-19 Study group; Kurth F., Ralser M. A proteomic survival predictor for COVID-19 patients in intensive care. PLOS Digit Health. (2022) Jan 18;1(1):e0000007. http://dx.doi.org/10.1371/journal.pdig.0000007
Gonzalez-Franquesa A., Gama-Perez P., Kulis M., Szczepanowska K., Dahdah N., Moreno-Gomez S., Latorre-Pellicer A., Fernández-Ruiz R., Aguilar-Mogas A., Hoffman A., Monelli E., Samino S., Miró-Blanch J., Oemer G., Duran X., Sanchez-Rebordelo E., Schneeberger M., Obach M., Montane J., Castellano G., Chapaprieta V., Sun W., Navarro L., Prieto I., Castaño C., Novials A., Gomis R., Monsalve M., Claret M., Graupera M., Soria G., Wolfrum C., Vendrell J., Fernández-Veledo S., Enríquez J.A., Carracedo A., Perales J.C., Nogueiras R., Herrero L., Trifunovic A., Keller M.A., Yanes O., Sales-Pardo M., Guimerà R., Blüher M., Martín-Subero J.I., Garcia-Roves P.M. Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. Redox Biol. (2022) 54:102353. http://dx.doi.org/10.1016/j.redox.2022.102353
Heidegger I., Fotakis G., Offermann A., Goveia J., Daum S., Salcher S., Noureen A., Timmer-Bosscha H., Schäfer G., Walenkamp A., Perner S., Beatovic A., Moisse M., Plattner C., Krogsdam A., Haybaeck J., Sopper S., Thaler S., Keller M.A., Klocker H., Trajanoski Z., Wolf D., Pircher A.. Comprehensive characterization of the prostate tumor microenvironment identifies CXCR4/CXCL12 crosstalk as a novel antiangiogenic therapeutic target in prostate cancer. Molecular Cancer (2022) 18;21(1):132. http://dx.doi.org/10.1186/s12943-022-01597-7
Sailer S., Lackner K., Pras-Raves M.L., Wever E.J.M., van Klinken J.B., Dane A.D., Geley S., Koch J., Golderer G., Werner-Felmayer G., Keller M.A., Zwerschke W., Vaz F.M., Werner E.R., Watschinger K.. Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown. J Lipid Res. (2022) 63(6):100222. http://dx.doi.org/10.1016/j.jlr.2022.100222
Schwärzler J., Mayr L., Vich Vila A., Grabherr F., Niederreiter L., Philipp M., Grander C., Meyer M., Jukic A., Tröger S., Enrich B., Przysiecki N., Tschurtschenthaler M., Sommer F., Kronberger I., Koch J., Hilbe R., Hess M.W., Oberhuber G., Sprung S., Ran Q., Koch R., Effenberger M., Kaneider N.C., Wieser V., Keller M.A., Weersma R.K., Aden K., Rosenstiel P., Blumberg R.S., Kaser A., Tilg H., Adolph T.E. PUFA-Induced Metabolic Enteritis as a Fuel for Crohn's Disease. Gastroenterology. (2022) 162(6):1690-1704. http://dx.doi.org/10.1053/j.gastro.2022.01.004
Oemer G., Edenhofer M.L., Wohlfarter Y., Lackner K., Leman G., Koch J., Cardoso L.H.D., Lindner H.H., Gnaiger E., Dubrac S., Zschocke J., Keller M.A. Erratum: Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. J Lipid Res. (2022) 63(4):100189. http://dx.doi.org/10.1016/j.jlr.2022.100189
Koch J., Watschinger K., Werner E.R., Keller M.A. Tricky Isomers-The Evolution of Analytical Strategies to Characterize Plasmalogens and Plasmanyl Ether Lipids. Front Cell Dev Biol. (2022) 27;10:864716. http://dx.doi.org/10.3389/fcell.2022.864716
Oemer G., Koch J., Wohlfarter Y., Lackner K., Gebert R.E.M., Geley S., Zschocke J., Keller M.A. The lipid environment modulates cardiolipin and phospholipid constitution in wild type and tafazzin‐deficient cells. Journal of Inherited Metabolic Disease. 45: 38–50 (2022). http://dx.doi.org/10.1002/jimd.12433
2021
Oemer G, Edenhofer ML, Wohlfarter Y, Lackner K, Leman G, Koch J, Cardoso LHD, Lindner HH, Gnaiger E, Dubrac S, Zschocke J, Keller MA. Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. J. Lipid Res. 62: 100111 (2021). http://dx.doi.org/10.1016/j.jlr.2021.100111
Keller MA. Interpreting phospholipid and cardiolipin profiles in rare mitochondrial diseases. Current Opinion in Systems Biology. 28: 100383 (2021). http://dx.doi.org/10.1016/j.coisb.2021.100383
Sailer S, Coassin S, Lackner K, Fischer C, McNeill E, Streiter G, Kremser C, Maglione M, Green CM, Moralli D, Moschen AR, Keller MA, Golderer G, Werner-Felmayer G, Tegeder I, Channon KM, Davies B, Werner ER, Watschinger K. When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping. Cell Biosci. 11: 54 (2021). http://dx.doi.org/10.1186/s13578-021-00566-9
Bartenbach L, Karall T, Koch J, Keller MA, Oberacher H, Scholl-Bürgi S, Karall D, Oemer G, Baumgartner D, Meinel K, Aly S, Odri-Komazec I, Geiger R, Michel M. Amino Acid and Phospholipid Metabolism as an Indicator of Inflammation and Subtle Cardiomyopathy in Patients with Marfan Syndrome. Metabolites. 11: 805 (2021). http://dx.doi.org/10.3390/metabo11120805
Vowinckel J, Hartl J, Marx H, Kerick M, Runggatscher K, Keller MA, Mülleder M, Day J, Weber M, Rinnerthaler M, Yu JSL, Aulakh SK, Lehmann A, Mattanovich D, Timmermann B, Zhang N, Dunn CD, MacRae JI, Breitenbach M, Ralser M. The metabolic growth limitations of petite cells lacking the mitochondrial genome. Nat Metab. 3: 1521–1535 (2021). http://dx.doi.org/10.1038/s42255-021-00477-6
Burtscher J, Syed MMK, Keller MA, Lashuel HA, Millet GP. Fatal attraction - The role of hypoxia when alpha-synuclein gets intimate with mitochondria. Neurobiol. Aging. 107: 128–141 (2021). http://dx.doi.org/10.1016/j.neurobiolaging.2021.07.017
Schoberleitner I, Bauer I, Huang A, Andreyeva EN, Sebald J, Pascher K, Rieder D, Brunner M, Podhraski V, Oemer G, Cázarez-García D, Rieder L, Keller MA, Winkler R, Fyodorov DV, Lusser A. CHD1 controls H3.3 incorporation in adult brain chromatin to maintain metabolic homeostasis and normal lifespan. Cell Rep. 37: 109769 (2021). http://dx.doi.org/10.1016/j.celrep.2021.109769
Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group; Ralser M, Kurth F. A time-resolved proteomic and prognostic map of COVID-19. Cell Systems (2021). http://dx.doi.org/10.1016/j.cels.2021.05.005
Rajeshwari M, Karthi S, Singh R, Efthymiou S, Gowda VK, Varalakshmi P, Srinivasan VM, Houlden H, Keller MA, Rizzo WB, Ashokkumar B. Novel ALDH3A2 mutations in structural and functional domains of FALDH causing diverse clinical phenotypes in Sjögren-Larsson syndrome patients. Hum. Mutat. (2021). http://dx.doi.org/10.1002/humu.24236
Sailer S, Keller MA, Werner ER, Watschinger K. The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification. Life. 11 (2021). http://dx.doi.org/10.3390/life11020088
Ferreira C., Rahman R.S., Keller M.A., Zschocke J., and ICIMD Advisory Group. An international classification of inherited metabolic disorders (ICIMD). J. Inherit. Metab. Dis. 44: 164–177 (2021). http://dx.doi.org/10.1002/jimd.12348
2020
Perez-Valencia JA, Gallon R, Chen Y, Koch J, Keller M, Oberhuber K, Gomes A, Zschocke J, Burn J, Jackson MS, Santibanez-Koref M, Messiaen L, Wimmer K. Constitutional mismatch repair deficiency is the diagnosis in 0.41% of pathogenic NF1/SPRED1 variant negative children suspected of sporadic neurofibromatosis type 1. Genet. Med. (2020). http://dx.doi.org/10.1038/s41436-020-0925-z
Locher M, Steurer M, Jukic E, Keller MA, Fresser F, Ruepp C, Wöll E, Verdorfer I, Gastl G, Willenbacher W, Weger R, Nachbaur D, Wolf D, Gunsilius E, Zschocke J, Steiner N. The prognostic value of additional copies of 1q21 in multiple myeloma depends on the primary genetic event. Am. J. Hematol. 95: 1562–1571 (2020). http://dx.doi.org/10.1002/ajh.25994
Koch, J., Lackner, K., Wohlfarter, Y., Sailer, S., Zschocke, J., Werner, E. R., Watschinger, K. & Keller, M. A. Unequivocal mapping of molecular ether lipid species by LC-MS/MS in plasmalogen-deficient mice. Analytical Chemistry (2020) https://doi.org/10.1021/acs.analchem.0c01933
Gonzalez-Franquesa, A., Gama-Perez, P., Kulis, M., Dahdah, N., Moreno-Gomez, S., Latorre-Pellicer, A., Fernández-Ruiz, R., Monelli, E., Samino, S., Miró, J., Oemer, G., Duran, X., Sanchez-Rebordelo, E., Schneeberger, M., Montane, J., Castellano, G., Chapaprieta, V., Prieto, I., Castaño, C., et al. Obesity causes irreversible mitochondria failure in visceral adipose tissue despite successful anti-obesogenic lifestyle-based interventions 2 3 Affiliations. Jose Antonio Enríquez 16, 21 (2020). https://doi.org/10.1101/2020.07.08.194167
Mayr, L., Grabherr, F., Schwärzler, J., Reitmeier, I., Sommer, F., Gehmacher, T., Niederreiter, L., He, G. W., Ruder, B., Kunz, K. T. R., Tymoszuk, P., Hilbe, R., Haschka, D., Feistritzer, C., Gerner, R. R., Enrich, B., Przysiecki, N., Seifert, M., Keller, M. A., et al. Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease. Nature Communications 11, 1–15 (2020). https://doi.org/10.1038/s41467-020-15646-6
Werner, E. R., Keller, M. A., Sailer, S., Lackner, K., Koch, J., Hermann, M., Coassin, S., Golderer, G., Werner-Felmayer, G., Zoeller, R. A., Hulo, N., Berger, J. & Watschinger, K. The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens. Proceedings of the National Academy of Sciences 201917461 (2020). https://doi.org/10.1073/pnas.1917461117
Michel, M., Dubowy, K.-O., Zlamy, M., Karall, D., Adam, M. G., Entenmann, A., Keller, M. A., Koch, J., Odri Komazec, I., Geiger, R., Salvador, C., Niederwanger, C., Müller, U., Scholl-Bürgi, S. & Laser, K. T. Targeted metabolomic analysis of serum phospholipid and acylcarnitine in the adult Fontan patient with a dominant left ventricle. Therapeutic Advances in Chronic Disease 11, 204062232091603 (2020). https://doi.org/10.1177/2040622320916031
Oemer, G., Koch, J., Wohlfarter, Y., Alam, M. T., Lackner, K., Sailer, S., Neumann, L., Lindner, H. H., Watschinger, K., Haltmeier, M., Werner, E. R., Zschocke, J. & Keller, M. A. Phospholipid Acyl Chain Diversity Controls the Tissue-Specific Assembly of Mitochondrial Cardiolipins. Cell Reports 30, 4281-4291.e4 (2020). https://doi.org/10.1016/j.celrep.2020.02.115
Huber, A., Galgóczy, L., Váradi, G., Holzknecht, J., Kakar, A., Malanovic, N., Leber, R., Koch, J., Keller, M. A., Batta, G., Tóth, G. K. & Marx, F. Two small, cysteine-rich and cationic antifungal proteins from Penicillium chrysogenum: A comparative study of PAF and PAFB. Biochimica et Biophysica Acta - Biomembranes 183246 (2020).https://doi.org/10.1016/j.bbamem.2020.183246
Koch, J., Lackner, K., Wohlfarter, Y., Sailer, S., Zschocke, J., Werner, E. R., Watschinger, K. & Keller, M. A. Unequivocal mapping of molecular ether lipid species by LC-MS/MS in plasmalogen-deficient mice. bioRxiv 2020.04.29.066530 (2020). https://doi.org/10.1101/2020.04.29.066530
Oemer, G., Edenhofer, M.-L., Lackner, K., Leman, G., Lindner, H. H., Dubrac, S., Zschocke, J. & Keller, M. A. Fatty Acyl Availability Modulates Cardiolipin Composition and Alters Mitochondrial Function in HeLa Cells. bioRxiv 2020.02.10.937433 (2020). https://doi.org/10.1101/2020.02.10.937433
2019
Huber, A., Oemer, G., Malanovic, N., Lohner, K., Kovács, L., Salvenmoser, W., Zschocke, J., Keller, M. A. & Marx, F. Membrane Sphingolipids Regulate the Fitness and Antifungal Protein Susceptibility of Neurospora crassa. Frontiers in Microbiology 10, 605 (2019). https://doi.org/10.3389/fmicb.2019.00605
Keller, M. A., Kampjut, D., Harrison, S. A., Driscoll, P. C. & Ralser, M. Reply to ‘Do sulfate radicals really enable a non-enzymatic Krebs cycle precursor?’ Nature ecology & evolution 3, 139–140 (2019). https://doi.org/10.1038/s41559-018-0792-z
Weustenfeld, M., Eidelpes, R., Schmuth, M., Rizzo, W. B., Zschocke, J. & Keller, M. A. Genotype and phenotype variability in Sjögren-Larsson syndrome. Human Mutation 40, 177–186 (2019). https://doi.org/10.1002/humu.23679
Gnaiger, E., Aasander Frostner, E., Abdul Karim, N., Abumrad, N., Acuna-Castroviejo, D., Adiele, R., Ahn, B., Ali, S., Alton, L., Alves, M., Amati, F., Amoedo, N., Andreadou, I., Arago, M., Aral, C., Arandarcikaite, O., Armand, A., Arnould, T., Avram, V., et al. Mitochondrial respiratory states and rate. (2019). https://doi.org/10.26124/MITOFIT:190001.V2
2018
Zelezniak, A., Vowinckel, J., Capuano, F., Messner, C. B., Demichev, V., Polowsky, N., Mülleder, M., Kamrad, S., Klaus, B.,Keller, M. A. & Ralser, M. Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts. Cell Systems 7, 269-283.e6 (2018). https://doi.org/10.1016/j.cels.2018.08.001
Keller, M. A., Driscoll, P. C., Messner, C. B. & Ralser, M. 1H-NMR as implemented in several origin of life studies artificially implies the absence of metabolism-like non-enzymatic reactions by being signal-suppressed. Wellcome Open Research 2, 52 (2018). https://doi.org/10.12688/wellcomeopenres.12103.2
Oemer, G., Lackner, K., Muigg, K., Krumschnabel, G., Watschinger, K., Sailer, S., Lindner, H., Gnaiger, E., Wortmann, S. B., Werner, E. R., Zschocke, J. & Keller, M. A. Molecular structural diversity of mitochondrial cardiolipins. Proceedings of the National Academy of Sciences of the United States of America 115, 4158–4163 (2018). https://doi.org/10.1073/pnas.1719407115
Werner, E. R., Keller, M. A., Sailer, S., Seppi, D., Golderer, G., Werner-Felmayer, G., Zoeller, R. A. & Watschinger, K. A novel assay for the introduction of the vinyl ether double bond into plasmalogens using pyrene-labeled substrates. Journal of Lipid Research 59, 901–909 (2018). https://doi.org/10.1194/jlr.D080283
Watschinger, K., Keller, M. A., Golderer, G., Coassin, S., Zschocke, J. & Werner, E. R. Biochemical characterization of AGMO variants implicated in relapses in visceral leishmaniasis. Journal of Infectious Diseases 217, 1846–1847 (2018). https://doi.org/10.1093/infdis/jiy090
2017
Naschberger, A., Orry, A., Lechner, S., Bowler, M. W., Nurizzo, D., Novokmet, M., Keller, M. A., Oemer, G., Seppi, D., Haslbeck, M., Pansi, K., Dieplinger, H. & Rupp, B. Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport. Structure 25, 1907-1915.e5 (2017). https://doi.org/10.1016/j.str.2017.10.006
Alam, M. T., Olin-Sandoval, V., Stincone, A., Keller, M. A., Zelezniak, A., Luisi, B. F. & Ralser, M. The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization. Nature Communications 8, (2017). https://doi.org/10.1038/ncomms16018
Keller, M. A., Kampjut, D., Harrison, S. A. & Ralser, M. Sulfate radicals enable a non-enzymatic Krebs cycle precursor. Nature Ecology and Evolution 1, 83–83 (2017). https://doi.org/10.1038/s41559-017-0083
2016
Sheridan, K. J., Lechner, B. E., Keeffe, G. O., Keller, M. A., Werner, E. R., Lindner, H., Jones, G. W., Haas, H. & Doyle, S. Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. Scientific Reports 6, 35306 (2016). https://doi.org/10.1038/srep35306
Keller, M. A., Zylstra, A., Castro, C., Turchyn, A. V, Griffin, J. L. & Ralser, M. Conditional iron and pH-dependent activity of a non-enzymatic glycolysis and pentose phosphate pathway. Science Advances 2 (2016). https://doi.org/10.1126/sciadv.1501235
Paglia, G., Stocchero, M., Cacciatore, S., Lai, S., Angel, P., Alam, M. T., Keller, M., Ralser, M. & Astarita, G. Unbiased Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism. Journal of Proteome Research 15, 608–618 (2016). https://doi.org/10.1021/acs.jproteome.5b01020
Campbell, K., Vowinckel, J., Keller, M. A. & Ralser, M. Methionine Metabolism Alters Oxidative Stress Resistance via the Pentose Phosphate Pathway. Antioxidants and Redox Signaling 24, 543–547 (2016). https://doi.org/10.1089/ars.2015.6516
2015
Campbell, K., Vowinckel, J., Mülleder, M., Malmsheimer, S., Lawrence, N., Calvani, E., Miller-Fleming, L., Alam, M. T., Christen, S., Keller, M. A. & Ralser, M. Self-establishing communities enable cooperative metabolite exchange in a eukaryote. eLife 4, (2015). https://doi.org/10.7554/eLife.09943
Piedrafita, G., Keller, M. A. & Ralser, M. The impact of non-enzymatic reactions and enzyme promiscuity on cellular metabolism during (Oxidative) stress conditions. Biomolecules 5, 2101–2122 (2015). https://doi.org/10.3390/biom5032101
Jack, C. V, Cruz, C., Hull, R. M., Keller, M. A., Ralser, M. & Houseley, J. Regulation of ribosomal DNA amplification by the TOR pathway. Proceedings of the National Academy of Sciences 112, 9674–9679 (2015). https://doi.org/10.1073/pnas.1505015112
Watschinger, K., Keller, M. A., McNeill, E., Alam, M. T., Lai, S., Sailer, S., Rauch, V., Patel, J., Hermetter, A., Golderer, G., Geley, S., Werner-Felmayer, G., Plumb, R. S., Astarita, G., Ralser, M., Channon, K. M. & Werner, E. R. Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome. Proc. Natl. Acad. Sci. U. S. A. 112,2431–2436 (2015). https://doi.org/10.1073/pnas.1414887112
Michel, S., Keller, M. A., Wamelink, M. M. C. & Ralser, M. A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance. BMC Genetics 16, (2015). https://doi.org/10.1186/s12863-015-0171-6
Keller, M. A., Piedrafita, G. & Ralser, M. The widespread role of non-enzymatic reactions in cellular metabolism. Current Opinion in Biotechnology 34, 153–161 (2015). https://doi.org/10.1016/j.copbio.2014.12.020
Timm, K. N., Hartl, J., Keller, M. A., Hu, D. E., Kettunen, M. I., Rodrigues, T. B., Ralser, M. & Brindle, K. M. Hyperpolarized [U-2H, U-13C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells. Magnetic Resonance in Medicine 74, 1543–1547 (2015). https://doi.org/10.1002/mrm.25561
Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin-Sandoval, V., Grüning, N. M., Krüger, A., Tauqeer Alam, M., Keller, M. A., Breitenbach, M., Brindle, K. M., Rabinowitz, J. D. & Ralser, M. The return of metabolism: Biochemistry and physiology of the pentose phosphate pathway. Biological Reviews 90, 927–963 (2015).https://doi.org/10.1111/brv.12140
2014
Keller, M. A., Zander, U., Fuchs, J. E., Kreutz, C., Watschinger, K., Mueller, T., Golderer, G., Liedl, K. R., Ralser, M., Kräutler, B., Werner, E. R. & Marquez, J. A. A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nature communications 5, 4439 (2014). https://doi.org/10.1038/ncomms5439
Keller, M. A., Turchyn, A. V. & Ralser, M. Non-enzymatic glycolysis and pentose phosphate pathway-like reactions in a plausible Archean ocean. Mol. Syst. Biol. 10, 725 (2014). https://doi.org/10.1002/msb.20145228
Grüning, N. M., Du, D., Keller, M. A., Luisi, B. F. & Ralser, M. Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis. Open Biology 4, 130232 (2014).https://doi.org/10.1098/rsob.130232
2013
Watschinger, K., Fuchs, J. E., Yarov-Yarovoy, V., Keller, M. A., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. & Werner, E. R. First insights into structure-function relationships of alkylglycerol monooxygenase. Pteridines 24, 99–103 (2013). https://doi.org/10.1515/pterid-2013-0007
Keller, M. A., Watschinger, K., Golderer, G., Werner-Felmayer, G. & Werner, E. R. Fatty aldehyde dehydrogenase, the enzyme downstream of tetrahydrobiopterin- dependent alkylglycerol monooxygenase. Pteridines 24, 105–109 (2013). https://doi.org/10.1515/pterid-2013-0004
Mayer, M., Keller, M. A., Watschinger, K., Werner-Felmayer, G., Werner, E. R. & Golderer, G. Expression of full-length human alkylglycerol monooxygenase and fragments in Escherichia coli. Pteridines 24, 111–115 (2013). https://doi.org/10.1515/pterid-2013-0014
2009-2012
Keller, M. A., Watschinger, K., Lange, K., Golderer, G., Werner-Felmayer, G., Hermetter, A., Wanders, R. J. A. & Werner, E. R. Studying fatty aldehyde metabolism in living cells with pyrene-labeled compounds. Journal of Lipid Research 53, 1410–1416 (2012). https://doi.org/10.1194/jlr.D025650
Watschinger K., Fuchs J.E., Yarov-Yarovoy V., Keller M.A., Golderer G., Hermetter A., Werner-Felmayer G., Hulo N., Werner E.R. Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol monooxygenase. Biochem J. (2012). 443(1): 279-86.
Watschinger K., Keller M.A., Golderer G., Hermann M., Maglione M., Sarg B., Lindner H., Hermetter A., Werner-Felmayer G., Konrat R., Hulo N., Werner E.R. Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes. Proc. Natl. Acad. Sci. USA. (2010) 107 (31): 13672-13677.
Keller M.A., Watschinger K., Golderer G., Maglione M., Sarg B., Lindner H.H., Terrinoni A., Beretta M., Mayer B., Werner-Felmayer G., Werner E.R. Monitoring of Fatty Aldehyde Dehydrogenase by Pyrenedecanal. J. Lipid Res. (2010) 51 (6):1554-9.
Keller M.A., Watschinger K., Golderer G., Maglione M., Werner-Felmayer G., Werner E.R. Role of Fatty Aldehyde Dehydrogenase in Ether Lipid Degradation Pathways. Pteridines (2009) 20(Special issue): 59-63.
Watschinger K., Keller M.A., Golderer G., Hermetter H., Maglione M., Prast H., Werner-Felmayer G., Werner E.R. Alkylglycerol monooxygenase: Properties of an orphan enzyme – an update. Pteridines (2009) 20(Special issue): 55-58.
Werner E.R., Hulo N., Watschinger K., Keller M.A., Golderer G., Werner-Felmayer G. Alkylglycerol monooxygenase candidate genes - is there a common protein motif for tetrahydrobiopterin interaction?. Pteridines (2009) 20(Special issue): 51-54.
Watschinger K., Keller M.A., Hermetter A., Golderer G., Werner-Felmayer G., Werner E.R. Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence. Biol Chem. (2009) 390(1):3-10.